Effect of Preoperative Albumin-to-Alkaline Phosphatase Ratio on Prognosis of Patients with Colorectal Cancer after Radical Surgery
JIN Aiyun
ZHANG Shuguang
WANG Daorong
WANG Helin
Abstract：Objective To explore the effect of preoperative albumin(ALB)-to-alkaline phosphatase(ALP)ratio(AAPR)on the prognosis of patients with colorectal cancer(CRC)after radical surgery.Methods A total of 109 patients who received radical resection of CRC from May 2017 to May 2019 were selected as the subjects of this study.The levels of ALB and ALP were detected and the AAPR ratio was calculated.According to the receiver operating characteristic(ROC)curve,the optimal cutoff point of AAPR was determined,which was divided into high AAPR group(n=48)and low AAPR group(n=61).Multivariate Cox regression analysis was used to analyze the risk factors affecting the prognosis of patients with CRC after radical resection.Results The area under the ROC curve(AUC)of preoperative AAPR in predicting the prognosis of patients after radical resection of CRC was 0.879(95%CI:0.787,0.971),the cut-off value was 0.53,the spe-cificity was81.06%,and the sensitivity was 83.25%.The 1-,2-and 3-year survival rates of low AAPR group were lower than those of high AAPR group(P＜0.05,P＜0.01).TNM stageⅢ-Ⅳ,lymph node metastasis and AAPR≤0.53 were risk factors for prognosis after radical resection of CRC(P＜0.01).Conclusion Preoperative AAPR has a certain evaluation val-ue for the prognosis of patients with CRC after radical resection,and the reduction of AAPR is an independent risk factor for poor prognosis of patients with CRC after radical resection.
Keywords：Colorectal neoplasmsAlbumin to alkaline phosphatase ratioSensitivityTNM stageLymphatic metas-tasisPrognosisRisk factorsPrediction
Publication Date：2024-06-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 30-33,52 )