Clinical Effect of Yiqi Huazhuo Lishui Formula Combined with Allopurinol in the Treatment of Chronic Heart Failure Complicated with Hyperurice-mia

CHEN Qiling; SUN Kai; TUO Jing

doi:10.3969/j.issn.1002-3429.2024.08.016

Abstract：Objective To investigate the effect of Yiqi Huazhuo Lishui formula combined with Allopurinol in the treatment of chronic heart failure(CHF)complicated with hyperuricemia.Methods A total of 105 patients with CHF and hyperuricemia who were treated from August 2021 to August 2023 were divided into three groups using the random number ta-ble method,with 35 patients in each group.All three groups received conventional treatment,and on this basis,the tradition-al Chinese medicine(TCM)group was treated with Yiqi Huazhuo Lishui formula,the Allopurinol group was treated with Allo-purinol,and the combination group was treated with Yiqi Huazhuo Lishui formula combined with Allopurinol.All groups were treated for 3 months.The clinical efficacy,serum uric acid,left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD),thromboxane B2(TXB2),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),high-sensitivity C-reactive protein(hs-CRP),N-terminal pro-brain natriuretic pep-tide(NT-proBNP),6-minute walking distance,nitric oxide(NO),endothelin(ET),calcitonin gene-related peptide(CGRP),and adverse reactions were compared among the three groups.Results The total effective rate of the combination group was94.29%(33/35),which was higher than that of the TCM group(74.29%,26/35)and the Allopurinol group(71.43%,25/35)(P＜0.05),but there was no significant difference between the TCM group and the Allopurinol group(P＞0.05).After treatment,the combination group had lower LVESD,LVEDD,NT-proBNP,hs-CRP,TXB2,TNF-α,ET,and IL-6 than the TCM group and the Allopurinol group,and a longer 6-minute walking distance than the TCM group and the Allopurinol group,and the LVEF,NO,and CGRP were higher than those of the TCM group and the Allopurinol group(P＜0.05);however,there was no significant difference between the TCM group and the Allopurinol group(P＞0.05).After treatment,the serum uric acid level was the lowest in the combination group,followed by the Allopurinol group and the TCM group(P＜0.05).There was no significant difference in the total incidence of adverse reactions among the three groups(P＞0.05).Conclusion The efficacy of the Yiqi Huazhuo Lishui formula combined with Allopurinol in the treatment of CHF pa-tients with hyperuricemia is reliable.It can regulate serum uric acid,inflammatory factors,and NT-proBNP levels,improve vascular endothelial function,promote cardiac function recovery,enhance exercise ability,and is highly safe.