Application Effect of Zhenqi Fuzheng Capsule and Zhenqi Fuzheng Decoc-tion in Patients with Advanced NSCLC Undergoing Adjuvant Chemothera-py
DU Xiaona
WANG Yongfu
ZHANG Meng
Abstract：Objective To investigate the application effect of Zhenqi Fuzheng capsule and Zhenqi Fuzheng decoction in advanced NSCLC patients undergoing adjuvant chemotherapy.Methods A total of 100 patients with advanced NSCLC un-dergoing chemotherapy from January 2021 to February 2023 were randomly divided into capsule group(n=50)and decoction group(n=50).The capsule group was given Zhenqi Fuzheng capsule,and the decoction group was given Zhenqi Fuzheng decoction.The clinical efficacy,toxic and side effects of chemotherapy and tumor markers[pro-gastrin releasing peptide(Pro-GRP),serum squamous cell carcinoma antigen(SCC-Ag),cytokeratin 19 fragment antigen 21-1(CYFRA21-1),carci-noembryonic antigen(CEA),neuron-specific enolase(NSE)],cellular immune function(CD3+,CD4+,CD8+,CD4+/CD8+),humoral immune function(IgA,IgM,IgG),survival status[Karnofsky performance status(KPS)],and cancer-related fatigue[Revised Piper Fatigue Scale(PFS-R)score]before and after treatment were compared between the two groups.Results There were no shedding cases in both groups.There was no significant difference in objective remission rate and disease control rate between capsule group[22.00%(11/50),92.00%(46/50)]and decoction group[26.00%(13/50),94.00%(47/50)](P＞0.05).After treatment,SCC,Pro-GRP,CEA,CYFRA21-1 and NSE in the two groups were lower than those before treatment(P＜0.05).There was no significant difference in the levels of CD3+,CD4+,CD8+,CD4+/CD8+and the levels of IgA,IgM and IgG between the two groups(P＞0.05).KPS score after treatment was higher than that before treatment,while PFS-R score was lower than that before treatment(P＜0.05).There was no sig-nificant difference in the incidence of toxic and side effects between the two groups(P＞0.05).Conclusion Zhenqi Fuzheng decoction and Zhenqi Fuzheng capsule have similar effects in adjuvant chemotherapy for advanced NSCLC patients.Both have equivalent effects in improving patients'immune function,reducing patients'cancer-related fatigue,and inhibiting the expression of tumor markers.
Keywords：Lung neoplasmsZhenqi Fuzheng capsuleZhenqi Fuzheng decoctionGastrin releasing peptide precur-sorCytokeratin fragment 19Carcinoembryonic antigenImmune functionCancer-related fatigue
Publication Date：2024-05-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 91-96 )