Efficacy of Sertraline Combined with Biofeedback in the Treatment of De-pression in Adolescents with Non-suicidal Self-injury

MA Lixin; DENG Qiaoen; SUN Yan

doi:10.3969/j.issn.1002-3429.2024.07.013

Abstract：Objective To investigate the effect of Sertraline combined with biofeedback therapy in the treatment of adolescent depression with non-suicidal self-injury(NSSI).Methods From March 2021 to February 2023,98 outpatient and inpatient adolescents with depression and NSSI were selected and divided into observation group(n=49)and the control group(n=49)according to random number table method.The observation group received Sertraline combined with biofeed-back therapy,and the control group received Sertraline.The course of treatment was 8 weeks.The clinical efficacy,Hamilton Depression Scale(HAMD)score,Self-rating Depression Scale(SDS)score,NSSI Behavior and Function Scale(ANSSIQ)score,serum dopamine(DA),5-hydroxytryptamine(5-HT)and homocysteine(Hcy)levels before and after treatment as well as adverse reactions during treatment and Treatment Emergent Symptom Scale(TESS)scores were compared.Results After treatment,the total effective rate of observation group(93.88%,46/49)was higher than that of the control group(77.55%,38/49)(P＜0.05).At 2,4 and 8 weeks after treatment,HAMD scores and SDS scores of the two groups showed a decreased trend compared with those before treatment,which were lower at 4 and 8 weeks after treatment in the ob-servation group than in the control group(P＜0.05).After treatment,the serum DA and 5-HT in the two groups were higher than those before treatment,which were higher in the observation group than in the control group(P＜0.05,P＜0.01).The scores of Hcy and ANSSIQ were lower than those before treatment,which were lower in the observation group than in the con-trol group(P＜0.05,P＜0.01).Conclusion Sertraline combined with biofeedback therapy is effective,which can improve the symptoms of depression and NSSI behavior in adolescents with depression and NSSI.