Efficacy of Live Combined Bacillus Subtilis and Enterococcus Faecium Granules with Multivitamines Combined with Disodium Cantharidinate and Vitamin B6 in the Treatment of Chronic Obstructive Pulmonary Disease Complicated with Non-small Cell Lung Cancer
CHEN Junjie
XIE Lina
JI Lijia
TIAN Xiuli
Abstract：Objective To investigate the efficacy of Live Combined Bacillus Subtilis and Enterococcus Faecium Gran-ules with Multivitamines combined with Disodium Cantharidinate and Vitamin B6 in the treatment of chronic obstructive pulmo-nary disease(COPD)complicated with non-small cell lung cancer(NSCLC).Methods A total of 60 patients with COPD combined with NSCLC from January 2020 to October 2022 were selected and divided into the observation group(n=30)and the control group(n=30)by random number table method.Both groups were given chemotherapy combined with immuno-therapy,on the basis of which the control group was given Disodium Cantharidinate and Vitamin B6,and the observation group was given Live Combined Bacillus Subtilis and Enterococcus Faecium Granules with Multivitamines Combined with Disodium Cantharidinate and Vitamin B6.Both groups were treated consecutively for 4 cycles.The total response rate after 4 cycles of treatment and the tumor factors[carcinoembryonic antigen(CEA),cancer antigen 125(CA125),vascular endothelial growth factor(VEGF),hypoxia inducible factor-1α(HIF-1α)],immune function indicators(CD3+,CD4+,CD4+/CD8+),and intestinal microecological index(intestinal flora richness and diversity index),toxic and side effects during treatment,and 1-year survival rate after treatment of the two groups before treatment and after 2 and 4 cycles of treatment were analyzed.Results There was no significant difference in the total remission rate between the two groups(P＞0.05).After treatment,CEA,CA125,VEGF and HIF-1α in the two groups decreased,while CD3+,CD4+and CD4+/CD8+increased,with statistical significance(P＜0.05).After treatment,the intestinal flora richness and diversity index of the two groups showed an increasing trend,which were higher in the observation group than in the control group(P＜0.05).The incidence of gas-trointestinal reactions in the observation group was 16.67%(5/30),which was lower than that in the control group(46.67%,14/30)(P＜0.05).There was no significant difference in 1-year survival rate between the two groups(P＞0.05).Conclusion Live Combined Bacillus Subtilis and Enterococcus Faecium Granules with Multivitamines Combined with Disodium Cantharidinate and Vitamin B6 can effectively correct the intestinal flora disturbance in COPD patients with NSCLC after chemotherapy and immunotherapy,improve the immune response,inhibit the expression of tumor factors,and reduce the occurrence of toxic and side effects.
Keywords：Pulmonary diseasechronicobstructiveLung tumorLive Combined Bacillus Subtilis and Enterococ-cus Faecium Granules with MultivitaminesDisodium Cantharidinate and Vitamin B6Carcinoembryonic antigenCD3+Toxic and side effectsSurvival rate
Publication Date：2024-05-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 37-42 )