Correlation between Blood Gas Analysis,Micro-inflammation Index,Pul-monary Function Grade,Frailty Degree and Prognosis in Elderly Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease Com-plicated with Frailty

FENG Jinping; LINGHU Hongxia

doi:10.3969/j.issn.1002-3429.2024.07.007

Abstract：Objective To analyze the correlation between blood gas analysis,micro-inflammation index,pulmonary function grade,frailty degree and prognosis in elderly patients with acute exacerbation of chronic obstructive pulmonary disease(COPD)complicated with frailty.Methods In total,106 elderly patients with acute exacerbation of COPD combined with frailty treated from January 2021 to January 2022 were selected as research subjects and divided into death group and survival group according to prognosis.The clinical data of the two groups were compared and multivariate Logistic regression analysis was performed to analyze the correlation of blood gas analysis,micro-inflammation index,pulmonary function grade and frailty degree with prognosis in elderly patients with acute exacerbation of COPD complicated with frailty.Results There was signifi-cant difference in pulmonary function grade and Groningen frailty indicator(GFI)score between the two groups(P＜0.01).The ratio of forced expiratory volume in the first second to forced vital capacity(FEV1/FVC),the percentage of forced expira-tory volume in the first second to the predicted value(FEV1%),oxygenation index(OI),blood oxygen saturation(SaO2)and arterial partial oxygen pressure(PaO2)in the death group were lower than those in the survival group.Tumor necrosis factor-α(TNF-α),C-reactive protein(CRP)and interleukin-8(IL-8)were significantly higher than those in survival group(P＜0.05,P＜0.01).Multivariate Logistic regression analysis showed that OI,SaO2,PaO2,CRP,TNF-α,IL-8,pulmona-ry function grade and GFI score were closely related to the prognosis of elderly patients with acute exacerbation of COPD com-bined with frailty(P＜0.05).Conclusion The blood gas analysis index,micro-inflammation index,pulmonary function grade and frailty degree of elderly patients with acute exacerbation of COPD combined with frailty are closely related to their prognosis.Clinical attention should be paid to the above indicators in these patients,and early targeted treatment measures are of great significance for improving the prognosis of elderly patients with acute exacerbation of COPD combined with frailty.