Effect of Combined Treatment with Danzhi Xiaoyao Pills on Infertility Caused by Liver-depression Type of Polycystic Ovary Syndrome Based on the Theory of Emotional Pathogenesis
ZHANG Jingjing
ZHU Ranran
LIU Na
MA Mei
LI Man
Abstract：Objective To study the effect of combined treatment with Danzhi Xiaoyao pills on infertility caused by liver-depression type of polycystic ovary syndrome(PCOS)based on the theory of Emotional Pathogenesis.Methods A total of 128 patients with infertility caused by liver-depression type of PCOS treated from July 2021 to October 2023 were selected and divided into CG group and EG group according to random number table method.CG group was treated with conventional western medicine,while EG group was treated with Danzhi Xiaoyao pills on the basis of CG group,and the clinical effect was observed after 3 menstrual cycles.The psychological status scores[Self-rating Depression Scale(SDS),self-rating Anxiety Scale(SAS)],serum sex hormone indexes[testosterone(T),estradiol(E2),luteinizing hormone(LH),follicle stimula-ting hormone(FSH)],endometrial tolerance indexes[dominant follicle number,endometrial thickness(Em)and uterine ar-tery pulse index(PI),resistance index(RI)]were compared between the two groups before and after treatment,and preg-nancy and adverse reactions were recorded.Results The total effective rate of EG group was 92.19%(59/64),which was higher than that of CG group[78.12%(50/64)](P＜0.05).After treatment,the scores of SAS and SDS,serum LH and T levels,uterine artery RI and PI in EG group were lower than those in CG group(P＜0.05).After treatment,the dominant follicle number,Em and serum E2 and FSH levels in EG group were higher than those in CG group(P＜0.05).After follow-up,the pregnancy rate in EG group was 65.62%(42/64),which was higher than that in CG group[37.50%(24/64)](P＜0.05).There were no significant differences in the abortion rate and the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion Combined treatment with Danzhi Xiaoyao pills has remarkable clinical effect in treating infertility caused by liver-depression type of PCOS.It can regulate sex hormone levels,promote follicle development,and en-hance endometrial receptivity,thereby increasing pregnancy rate.
Keywords：Polycystic ovary syndromeLiver depression syndromeInfertilityEmotional PathogenesisDanzhi Xi-aoyao pillsDepressionEstradiolPregnancy outcome
Publication Date：2024-05-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 77-81 )