Relationship between Serum CTRP9 and Gal-3 Levels and Ventricular Ar-rhythmia in Patients with Chronic Heart Failure and Their Predictive Val-ue for Ventricular Arrhythmia
YUAN Yumin
SONG Lei
LU Yingmin
YUE Dongmei
Abstract：Objective To investigate the relationship between serum levels of complement C1q tumor necrosis factor related protein 9(CTRP9)and galactose agglutinin 3(Gal-3)and ventricular arrhythmia in patients with chronic heart failure(CHF),and their predictive value for ventricular arrhythmia.Methods A total of 120 patients with CHF admitted from Oc-tober 2021 to October 2022 were selected and divided into occurrence group(n=41)and non-occurrence group(n=79)ac-cording to occurrence of ventricular arrhythmia.Clinical data and serum CTRP9 and Gal-3 levels of the two groups were com-pared to analyze the influencing factors of ventricular arrhythmia in CHF patients.The impact of serum CTRP9 and Gal-3 in-teraction on the risk of ventricular arrhythmia in CHF patients was analyzed,and the predictive value of serum CTRP9 and Gal-3 on ventricular arrhythmia in CHF patients was evaluated.The prognosis of CHF patients with different serum CTRP9 and Gal-3 levels was compared.Results There were significant differences in cardiac function grade,left ventricular ejection fraction and average heart rate between the two groups(P＜0.01).The serum CTRP9 level in the occurrence group was lower than that in the non-occurrence group,while the serum Gal-3 level was higher than that in the non-occurrence group(P＜0.01).Logistic regression analysis showed that cardiac function grade,left ventricular ejection fraction,average heart rate,and serum CTRP9 and Gal-3 levels were all influencing factors for ventricular arrhythmia in CHF patients(P＜0.01),and there was additive interaction between serum CTRP9 and Gal-3 levels.Receiver operating characteristic(ROC)curve analysis showed that the area under the ROC curve of serum CTRP9 and Gal-3 in combination in predicting ventricular arrhythmia in CHF patients was 0.941,which was higher than that predicted by each index alone(0.802 and 0.714,respectively).Taking the mean values of serum CTRP9 and Gal-3 in 120 CHF patients as the boundary,the incidence rate of adverse cardiovascular events in patients with high serum CTRP9 level was lower than that in patients with low CTRP9 level,while the incidence rate of adverse cardiovascular events in patients with high serum Gal-3 level was higher than that in patients with low Gal-3 level(P＜0.05).Conclusion The decrease of CERP9 level and the increase of Gal-3 level in CHF patients are related to the oc-currence of ventricular arrhythmia.Clinical detection of serum CERP9 and Gal-3 is helpful to predict the risk of ventricular ar-rhythmia.
Keywords：Heart failureArrhythmiaComplement C1q tumor necrosis factor-associated protein 9Galectin-3Cardiac functionHeart rateLeft ventricular ejection fractionLogistic regression analysis
Publication Date：2024-05-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 42-47 )