Evaluation Value of Detection of Serum ICAM-1,IL-10 and TNF-α in Combination for Prognosis of Burn Patients
GAO Xuepo
JIA Hongfei
LI Maoqing
Abstract：Objective To investigate the changes of serum intercellular adhesion molecule-1(ICAM-1),interleukin-10(IL-10)and tumor necrosis factor-α(TNF-α)levels and their combined detection in the prognosis of burn patients.Methods A total of 179 burn patients admitted to the Burn Department from June 2019 to March 2022 were selected and di-vided into survival group and death group according to the prognosis.Serum levels of ICAM-1,IL-10 and TNF-α were com-pared between the two groups at 1,3,5 and 7 d after admission.The correlation between serum ICAM-1,IL-10 and TNF-α in burn patients was analyzed by Pearson correlation,and the predictive value of serum ICAM-1,IL-10 and TNF-α in progno-sis of burn patients was evaluated by receiver operating characteristic(ROC)curve.Results In total,179 burn patients were divided into survival group(n=150)and death group(n=29)according to prognosis.Serum ICAM-1,IL-10 and TNF-α levels in the survival group were firstly increased and then decreased,reaching the peak value on the 5th,3rd and 3rd d after admission,respectively(P＜0.01),while the serum ICAM-1,IL-10 and TNF-α levels in the death group were gradually increased(P＜0.01).The levels of serum ICAM-1,IL-10 and TNF-α were significantly different between the two groups on the 1st,3rd,5th and 7th d after admission(P＜0.01).The levels of ICAM-1,IL-10 and TNF-α in serum at dif-ferent time points were significantly different(P＜0.01),and there was interaction between groups and time points(P＜0.01).Pearson correlation analysis showed a positive correlation among serum ICAM-1,IL-10 and TNF-α in burn patients(P＜0.05).ROC curve analysis showed that the area under the curve(AUC)of ICAM-1,IL-10 and TNF-αin predicting the prognosis of burn patients was 0.758,0.765,and 0.775,respectively,whereas AUC of the three in combination in predicting the prognosis of burn patients was 0.824.Conclusion The serum ICAM-1,IL-10 and TNF-α of burn patients are elevated,and the combined detection has high application value in evaluating the prognosis of burn patients in clinical practice,which is conducive to early intervention measures.
Keywords：BurnsIntercellular adhesion molecule-1Interleukin-10Tumor necrosis factor-αPrognosisCorrela-tionReceiver operating characteristic curvePredictive value
Publication Date：2024-04-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 48-54 )