Effect of Recombinant Human Epidermal Growth Factor Combined with Nano-silver Dressing on Burn and Its Impact on Serum Inflammatory Fac-tor Level

LI Maoqing; JIA Hongfei; GAO Xuepo

doi:10.3969/j.issn.1002-3429.2024.04.015

Abstract：Objective To investigate the effect of recombinant human epidermal growth factor(rh-EGF)combined with nano-silver dressing in the treatment of burn patients and its impact on wound healing,pain,and serum inflammatory fac-tor levels.Methods A total of 100 patients with burn treated from January 2020 to January 2022 were selected as the re-search subjects and divided into two groups according to different treatment methods,with 50 patients in each group.The con-trol group was treated with rh-EGF,and the observation group was supplemented with nano-silver dressing on the basis of the control group.The levels of intercellular adhesion factor-1(ICAM-1),interleukin-10(IL-10)and tumor necrosis factor-α(TNF-α)were compared between the two groups before and after treatment,and the time of burn secretions,the disappear-ance of inflammatory symptoms and the time of wound healing in the two groups were recorded.The wound pain during dress-ing change before and after treatment was evaluated by numerical pain score(NRS).The wound healing rate of the two groups was calculated,the scar condition of the two groups was evaluated by Vancouver Scar Scale(VSS),and the incidence of ad-verse reactions in the two groups was analyzed.Results Compared with those before treatment,the levels of serum ICAM-1 and TNF-α were decreased and IL-10 was increased in the two groups at 7 d after treatment,and the changes were more signif-icant in observation group(P＜0.01).At 7 and 14 d after treatment,the positive rate of burn secretion culture in the obser-vation group was lower than that in the control group(P＜0.05).The disappearance time of inflammatory symptoms,the time of 50%wound healing,the time of 80%wound healing and the time of 100%wound healing in the observation group were shorter than those in the control group,and the wound healing rate was higher than that in the control group(P＜0.01,P＜0.05).NRS scores at 14 d after treatment and VSS score at 6 months after treatment in both groups were lower than those be-fore treatment,which were lower in the observation group than in the control group(P＜0.05).Conclusion rh-EGF com-bined with nano-silver dressing can promote wound healing,improve the degree of wound pain and reduce the level of serum inflammatory factors.