Clinical Effect and Related Mechanism of Supplemented Siwu Wuchen De-coction in Treating Low Menstrual Volume Caused by Endometrial Injury in Patients with Liver-stagnation and Blood-stasis Syndrome
MEI Li
LIU Huahua
HUANG Aihong
LIU Kaiyan
Abstract：Objective To investigate the clinical effect and related mechanism of supplemented Siwu Wuchen decoc-tion in treating low menstrual volume caused by endometrial injury in patients with liver-stagnation and blood-stasis syndrome.Methods A total of 180 patients with endometrial injury caused by liver-stagnation and blood-stasis syndrome treated from January 2020 to December 2022 were randomly divided into control group and observation group,with 90 cases in each group.The control group was treated with conventional Western medicine,and the observation group was treated with supplemented Siwu Wuchen decoction on this basis for 6 consecutive menstrual cycles.The clinical efficacy,TCM syndrome score,endome-trial thickness,blood volume,duration of menstruation,endometrial arterial blood flow[pulsation index(PI),vascular re-sistance index(RI),peak systolic velocity(PSV)],sex hormone[estradiol(E2),luteinizing hormone(LH),prolactin(PRL),follicle stimulating hormone(FSH)],vascular endothelial growth factor(VEGF)/transforming growth factor-β1(TGF-β1)signaling pathway-related factors and adverse reactions were compared between the two groups.Results The total effective rate of observation group was91.11%(82/90),which was higher than that of control group[76.67%(69/90)](P<0.05).After 3 and6 cycles of treatment,the scores of TCM syndromes in the observation group were lower than those in the control group,the blood volume and endometrial thickness in the observation group were higher than those in the control group,and the duration of menstruation was longer than that in the control group(P<0.05).After 3 and 6 cycles of treat-ment,RI,PI,PRL and FSH in observation group were lower than those in control group,while PSV,E2,LH,VEGF and TGF-β1 were higher than those in control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Modified Siwu Wuchen decoction has good clinical effects in treating low menstrual volume caused by endometrial injury in patients with liver-stagnation and blood-stasis syndrome,and can improve clinical symptoms and endometrial blood perfusion,the mechanism of which may be related to improving endome-trial thickness,regulating sex hormone levels and VEGF/TGF-β1 signaling pathway.
Keywords：Endometrial injuryLow menstrual volumeliver-stagnation and blood-stasisSupplemented Siwu Wuchen decoctionSyndromeEstradiolVascular endothelial growth factorTransforming growth factor-β1
Publication Date：2024-03-22
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 136-142 )