Study on the Synergistic and Attenuating Effects of Thymalfasin on Paclita-xel Combined with Cisplatin Regimen in the Treatment of Advanced Esophageal Cancer
XU Changlong
WANG Qianhui
Abstract：Objective To explore the synergistic and attenuating effects of Thymalfasin on paclitaxel combined with cisplatin(TP)regimen in the treatment of advanced esophageal cancer.Methods A total of 120 patients with moderate and advanced esophageal cancer treated from June 2021 to June 2023 were randomly divided into observation group(n =60)and control group(n =60).The control group was treated with TP regimen,and the observation group was treated with Thymalfa-sin combined with TP regimen.The efficacy,improvement rate of quality of life,toxicity,1-year survival rate and the levels of T lymphocyte subsets,carcinoembryonic antigen(CEA),squamous cell carcinoma antigen(SCC-Ag)and carbohydrate anti-gen 19-9(CA19-9)before and after treatment were compared between the two groups.Results The objective remission rate,improvement rate of quality of life and 1-year survival rate in observation group were higher than those in control group,while the incidence of nausea,vomiting and myelosuppression was lower than that in control group(P<0.05).After 1 and 4 cour-ses of treatment,CD8 +,CD4 +,CD3 +,and CD4 +/CD8 + in the observation group had a higher improvement than that in the control group(P<0.05).Serum CEA,SCC-Ag and CA19-9 levels in the two groups after 1 and 4 courses of treatment were lower than those before treatment,and lower in the observation group than in the control group(P<0.05).Conclusion Thymalfasin can enhance the immune function of the body and play a synergistic and attenuating role in the treatment of ad-vanced esophageal cancer by TP regimen.
Keywords：Esophageal neoplasmsSynergistic and attenuating effectPaclitaxelThymalfasinCisplatinT-LymphocytesCarcinoembryonic antigenSquamous cell carcinoma antigen
Publication Date：2024-03-22
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 114-118 )