Effects of Combination of Vitamin D3,rTMS and Aripiprazole on Serum 25-(OH)D3,BDNF and Cognitive Impairment Indicators in Patients with Schizophrenia
HE Fengying
HE Lanying
LI Sushui
ZHANG Cuifang
LI Yunliang
SUN Yan
Abstract：Objective To investigate the effects of vitamin D3 combined with repetitive transcranial magnetic stimula-tion(rTMS)and Aripiprazole on schizophrenia and their effect on serum 25-hydroxyvitamin D3[25-(OH)D3],brain-derived nerve growth factor(BDNF)and cognitive impairment index.Methods A total of 104 patients with schizophrenia admitted from January 2022 to March 2023 were selected and divided into two groups,the observation group(n =52)and the control group(n =52),according to different treatment methods.The observation group was treated with vitamin D3 combined with rTMS and Aripiprazole,while the control group was treated with rTMS and Aripiprazole.Clinical efficacy after treatment,psy-chiatric symptoms before and after treatment[the positive and negative symptom scale(PANSS)score],cognitive impairment indexes[insulin-like growth factor-1(IGF-1),nerve cell adhesion molecule(NCAM),Galectin-3],electroencephalogram and astroglial derived protein(S100B),25-(OH)D3,and BDNF level before and after treatment as well as incidence of ad-verse reactions during treatment were observed.Results The total effective rate of observation group was94.23%(49/52),which was higher than that of control group[80.77%(42/52)](P<0.05).After treatment,score of each item of PANSS,α wave amplitude and serum S100B level in observation group were lower than those in control group,while θ wave amplitude and the serum levels of IGF-1,NCAM,Galectin-3,25-(OH)D3 and BDNF levels in observation group were higher than those in control group(P<0.05,P<0.01).There was no significant difference in the incidence of adverse reactions between the two groups during treatment(P>0.05).Conclusion Vitamin D3 combined with rTMS,and Aripiprazole can improve the clinical effect of schizophrenia,alleviate psychiatric symptoms,improve EEG abnormalities,and reduce cognitive impairment indexes.
Keywords：SchizophreniaVitamin D3Repetitive transcranial magnetic stimulationAripiprazoleSerum 25-hydroxyvitamin D3Brain-derived nerve growth factorCognitive ImpairmentElectroencephalogram
Publication Date：2024-03-22
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 52-57 )