Effect of Astragalus Injection and Angelica Injection in the Adjuvant Treat-ment of Multiple Myeloma

YANG Lei; GONG Jingzhi; LI Nan

doi:10.3969/j.issn.1002-3429.2024.02.023

Abstract：Objective To explore the effect of Astragalus injection and Angelica injection in the adjuvant treatment of multiple myeloma.Methods A total of 160 patients with multiple myeloma treated from January 2019 to December 2022 were selected and divided into four groups according to random number table method,with 40 cases in each group.The control group was given bortezomib,thalidomide,dexamethasone(VTD)chemotherapy,the Astragalus group was given Astragalus injection combined with VTD regimen,the Angelica group was given Angelica injection combined with VTD regimen,and the combination group was given Astragalus injection and Angelica injection combined with VTD program.The clinical efficacy,incidence of toxic and side effects,quality of life and serum biochemical indexes[β2-microbulin(β2-MG),free light chain κ(FLC-κ),FLC-λ,interleukin-6(IL-6),C reactive protein(CRP),alkaline phosphatase(ALP)and total procollagen type I N-terminal propeptide(TPINP),osteocalcin(BGP)]before and after treatment were compared between the four groups.Results The total effective rate and the improvement rate of quality of life in combination group,Astragalus group and Angel-ica group were higher than those in control group,and the incidence of infection,bone marrow suppression,peripheral neu-ropathy and gastrointestinal reaction were lower than those in control group(P＜0.05).After 2 and 4 courses of treatment,IL-6,CRP,β2-MG,FLC-κ,FLC-λ and TPINP in the four groups were decreased compared with those before treatment,which were lower in the combination group than in the Astragalus group,Angelica group and control group,and lower in the Astragalus group and Angelica group than in the control group(P＜0.05).ALP and BGP in the four groups were higher than those before treatment,which were higher in the combination group than in Astragalus group,Angelica group and control group,and higher in Astragalus group and Angelica group than in the control group(P＜0.05).There was no significant difference in the above serum biochemical indexes between Astragalus group and Angelica group(P＞0.05).Conclusion Astragalus injection and Angelica injection combined with VTD regimen in the treatment of multiple myeloma can enhance the immune function and anti-cancer ability of patients,and the incidence of toxic and side effects can be significantly reduced,showing significant effects.