Clinical Effect of Paishi Decoction Combined with Phloroglucinol on Post-operative Adjuvant Treatment of Kidney Stones with Damp-heat Accumu-lation Syndrome after Holmium Laser Lithotripsy

MA Huixi; LI Bin; ZHANG Lei; LU Yazhou; AN Fuju

doi:10.3969/j.issn.1002-3429.2024.02.021

Abstract：Objective To explore the clinical effect of Paishi Decoction combined with Phloroglucinol on postopera-tive adjuvant treatment of kidney stones with damp-heat accumulation syndrome after holmium laser lithotripsy.Methods A total of 200 patients with kidney stones with damp-heat accumulation syndrome treated by holmium laser lithotripsy from May 2020 to May 2022 were prospectively selected as the research subjects,and were divided into observation group one,observa-tion group two,observation group three and control group by random number table method,with 50 cases in each group.The control group received conventional treatment after operation.On this basis,observation group one was given Paishi decoction combined with Phloroglucinol,observation group two was given Paishi decoction and observation group three was given Phloro-glucinol.The effect of stone clearance in the four groups was compared.TCM syndrome score,renal aorta hemodynamics[peak systolic velocity(Vmax),systolic peak velocity(S),end-diastolic peak velocity(D),resistance index(RI)],oxida-tive stress index[superoxide dismutase(SOD),malondialdehyde(MDA),lipid peroxide(LPO)]and comfort level(cathe-ter-related symptom scores)were compared before and after treatment.Results The stone clearance rate of observation group one was higher than that of observation group two,observation group three and control group(P＜0.05).At 3 and 7 d after treatment,the TCM syndrome scores,catheter-related symptom scores,RI and serum MDA and LPO levels of observation group one were lower than those of observation group two,observation group three and control group,which were lower in ob-servation group two and observation group three than in control group(P＜0.05).At 3 and 7 d after treatment,the Vmax,S/D and serum SOD levels in observation group one were higher than those in observation group two,observation group three and control group,which were higher in observation group two and observation group three than in control group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the four groups(P＞0.05).Conclusion After holmium laser lithotripsy,Paishi decoction combined with Phloroglucinol given can improve the effect of stone clearance,improve renal hemodynamics,reduce oxidative stress reaction,relieve symptoms and improve comfort.