Effects of Combined Anesthesia with Flurbiprofen Axetil and Propofol on Pulmonary Oxygenation Function,Hemodynamics and Respiratory Com-pliance in Elderly Patients with Lung Cancer Undergoing Lobectomy

BAO Mengmeng; WU Anshi

doi:10.3969/j.issn.1002-3429.2024.01.019

Abstract：Objective To analyze the effects of combined anesthesia with Flurbiprofen Axetil and Propofol on periop-erative pulmonary oxygenation function,hemodynamics and respiratory compliance in elderly patients with lung cancer under-going lobectomy.Methods A total of 100 elderly patients who underwent pulmonary lobectomy for lung cancer from January 2020 to June 2022 were selected as the research subjects and divided into observation group(n =50)and control group(n = 50)according to different perioperative anesthesia methods.The observation group was given combined anesthesia with Flurbi-profen Axetil and Propofol before single lung ventilation,and the control group was given intravenous anesthesia of Propofol be-fore single lung ventilation.The intraoperative dosage of Propofol was observed and compared between the two groups.Pulmo-nary oxygenation function indexes[partial pressure of oxygen(PaO2),partial pressure of carbon dioxide(PaCO2),oxygena-tion index(OI)],hemodynamic indexes[mean arterial pressure(MAP),heart rate(HR)]and respiratory compliance in-dexes[dynamic pulmonary compliance(Cdyn)]at different time points[before induction of anesthesia(T1),at 30 min after single lung ventilation(T2),at 60 min after single lung ventilation(T3)and immediately after operation(T4)],and the oc-currence of postoperative complications were compared between the two groups.Results Intraoperative dosage of Propofol in the observation group was(110.32±3.89)mg,which was significantly lower than that in the control group[(168.21±4.86)mg](P＜0.01).At T1 and T4,there were no significant differences in PaO2,PaCO2,OI,MAP,HR and Cdyn be-tween the two groups(P＞0.05).Compared with those at T1,PaO2,PaCO2,OI,HR and Cdyn in the two groups were sig-nificantly decreased at T2 and T3,while MAP was significantly increased(P＜0.05).At T2 and T3,PaO2,OI and Cdyn in the observation group were higher than those in the control group,while MAP and HR were significantly lower than those in the control group(P＜0.05,P＜0.01).The total incidence of postoperative complications in the observation group[18.00%(9/50)]was lower than that in the control group[54.00%(27/50)](P＜0.01).Conclusion Flurbiprofen Axetil com-bined with Propofol has a definite anesthetic effect on elderly lung cancer patients undergoing pulmonary lobectomy under sin-gle lung ventilation,which can significantly reduce intraoperative dosage of Propofol,improve perioperative pulmonary oxygen-ation function and hemodynamics,improve respiratory compliance,effectively protect lung function,and have good safety.