Correlation between Serum LDL-C/HDL-C,Non-HDL-C,RLP-C and sLOX-1 Levels and Acute Cerebral Infarction in Elderly Patients
ZHANG Meng
LIU Haiying
QI Chang
Abstract：Objective To analyze the correlation of the levels of serum low-density lipoprotein cholesterol(LDL-C)/high-density lipoprotein cholesterol(HDL-C),non-high-density lipoprotein cholesterol(non-HDL-C),residual lipoprotein cholesterol(RLP-C)and soluble Lectin-like oxidized low density lipoprotein receptor-1(sLOX-1)with acute cerebral infarc-tion(ACI).Methods A total of 230 elderly ACI patients admitted from January 2022 to August 2023 were selected as the research group,and 115 healthy physical examinees of the same age group during the same period were selected as the control group.The levels of LDL-C/HDL-C,non-HDL-C,RLP-C and sLOX-1 were compared between the two groups,and the above levels of patients with different plaque stability,neurological deficit[assessed by the National Institutes of Health Stroke Scale(NIHSS)score]and carotid intimedia thickness(IMT)in the research group were compared.Partial regression analysis was performed to analyze the relationship between the above indexes and ACI,and the correlation between the above indexes and plaque stability,IMT and NIHSS score.Results LDL-C/HDL-C,non-HDL-C,RLP-C and sLOX-1 levels in the research group were higher than those in the control group(P＜0.01).For elderly ACI patients,LDL-C/HDL-C,non-HDL-C,RLP-C and sLOX-1 levels were lower in non-plaque patients,followed by stable plaque patients and unstable plaque patients,lower in mild neurological deficit patients,followed by moderate neurological deficit patients and severe neurological deficit pa-tients,and lower in normal IMT patients,followed by IMT thickening patients and plaque formation patients(P＜0.05).LDL-C/HDL-C,non-HDL-C,RLP-C and sLOX-1 levels were closely correlated with ACI in the elderly(P＜0.01).LDL-C/HDL-C,non-HDL-C,LDL-C and sLOX-1 levels in the research group were positively correlated with plaque stability,IMT and NIHSS score,respectively(P＜0.01).Conclusion LDL-C/HDL-C,non-HDL-C,RLP-C and sLOX-1 levels in elderly ACI patients are significantly increased,which is closely related to the degree of neurological deficit and carotid atherosclerotic plaque in patients,and provides guidance for clinical diagnosis and treatment.
Keywords：Acute cerebral infarctionLow-density lipoprotein cholesterolHigh-density lipoprotein cholesterolNon-high-density lipoprotein cholesterolRemnant-like particle cholesterolSoluble lectin-like oxidized low-density lipoprotein receptor-1ElderlyCorrelati
Publication Date：2024-01-22
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 83-88 )