Relationship between Intestinal Flora and Adverse Cardiovascular Events in Patients with Coronary Heart Disease after Percutaneous Coronary In-tervention
WANG Yuhang
JIA Xiaojing
GUO Li
XING Yuanyuan
LI Haonan
XU Peng
Abstract：Objective To analyze the relationship between intestinal flora and major adverse cardiovascular events(MACE)after percutaneous coronary intervention(PCI)in patients with coronary heart disease(CHD).Methods In total,150 CHD patients treated with PCI from March 2021 to March 2022 were selected and divided into MACE group and non-MACE group according to whether MACE occurred one year after discharge.The clinical data of the two groups were com-pared,and the risk factors of MACE occurrence in CHD patients after PCI were determined by multivariate Logistic regression analysis.Results Follow-up revealed that the incidence of MACE in CHD patients after PCI was32.67%(49/150).Com-pared with the non-MACE group,the MACE group had a higher proportion of people aged≥60 years,a higher incidence of hypertension,a higher Gensini score,homocysteine(Hcy)level,and alkaline phosphatase(ALP)level,and a lower number of lactobacilli,bifidobacteria,and Escherichia coli(P＜0.05,P＜0.01).Multivariate Logistic regression analysis showed that age≥60 years,combined hypertension,high Gensini score,high Hcy level,high ALP level,and a lower number of lac-tobacillus and bifidobacterium were the risk factors for MACE in CHD patients after PCI(P＜0.01).Conclusion A lower number of Lactobacillus and bifidobacterium are independent risk factors for MACE in CHD patients after PCI,and intestinal flora disturbance is correlated with MACE in CHD patients after PCI.
Keywords：Coronary diseasePercutaneous coronary interventionMajor adverse cardiovascular eventIntestinal floraLactobacillusBifidobacteriumInfluencing factor analysisCorrelation
Publication Date：2024-01-22
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 48-52 )