Sanjie Tongluo Yishen Xiezhuo Method Combined with Allopurinol Sus-tained Release Capsule in the Treatment of Early Gouty Nephropathy and Its Effect on Symptom Improvement and Biochemical Indexes

LI Fuliang; WANG Jianwei; SHEN Yue

doi:10.3969/j.issn.1002-3429.2023.12.028

Abstract：Objective To investigate the effect of Sanjie Tongluo Yishen Xiezhuo method combined with Allopurinol sustained release capsule in the treatment of early gouty nephropathy(GN)and its effect on the improvement of symptoms and biochemical indexes of patients.Methods Sixty patients with early GN treated from October 2020 to May 2022 were selected and divided into observation group(n =30)and control group(n =30)according to different treatment methods.The obser-vation group was treated with Sanjie Tongluo Yishen Xiezhuo method combined with Allopurinol sustained release capsules,and the control group was treated with Allopurinol sustained release capsules.The clinical effects at 8 weeks after treatment,TCM syndrome scores,renal function indexes,serum inflammatory factors,and T lymphocyte subsets at 4 weeks and 8 weeks after treatment as well as adverse reactions during treatment were compared between the two groups.Results At 8 weeks after treatment,the total effective rate of observation group[90.00%(27/30)]was higher than that of control group[66.67%(20/30)](P<0.05).Compared with those before treatment,the main TCM syndrome score,secondary syndrome score,total score,renal function index,serum inflammatory factors,CD3 +/CD8 +,and CD4 +/CD8 + were decreased at 4 and 8 weeks after treatment,while both CD3 + and CD3 +/CD4 + were increased(P<0.05).Compared with those at 4 weeks af-ter treatment,the main TCM symptom score,secondary symptom score,total score,renal function index,serum inflammatory factors,CD3 +/CD8 +,and CD4 +/CD8 + were also decreased at 8 weeks after treatment in the two groups,while CD3 + and CD3 +/CD4 + were also increased(P<0.05).At 4 and 8 weeks after treatment,the main TCM syndrome score,sec-ondary syndrome score,total score,renal function index,serum inflammatory factors,CD3 +/CD8 +,and CD4 +/CD8 + in the observation group were lower than those in the control group,while CD3 + and CD3 +/CD4 + were higher than those in the control group(P<0.05).During treatment,there was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Sanjie Tongluo Yishen Xiezhuo method combined with Allopurinol sus-tained release capsule has a reliable effect in the treatment of early GN patients,which can reduce inflammatory damage,im-prove immune function,improve clinical symptoms and promote renal function,with good safety.