Observation on the Clinical Effect of Combined Treatment of Chronic Ne-phritis of Spleen-kidney Deficiency Type with Sanbai Yishen Formula
CHEN Lixiang
YU Hemei
WANG Chunning
XU Shufen
GAO Fushun
Abstract：Objective To investigate the clinical effect of Sanbai Yishen Formula in the combined treatment of chron-ic nephritis of spleen-kidney deficiency type,and to analyze its effect on traditional Chinese medicine(TCM)syndrome score and renal function.Methods A total of 110 patients with chronic nephritis of spleen and kidney deficiency type admitted from January 2020 to January 2022 were selected as the research subjects and randomly divided into a control group and an ob-servation group,with 55 cases in each group.The control group received basic treatment combined with conventional Western medicine treatment,while the observation group received Sanbai Yishen formula on this basis.The clinical efficacy,efficacy of TCM syndrome,incidence of adverse reactions,and 24-hour urine protein quantitation,TCM syndrome scores before treat-ment,at 1 month and 2 months after treatment were statistically analyzed in both groups.The renal function indicators[serum creatinine(Scr),urinary albumin creatinine ratio(UACR),blood urea nitrogen(BUN),urinary red blood cell count],mi-croinflammatory state,and immune function(CD3 +,CD4 +,CD4 +/CD8 +)levels before and after treatment were com-pared between the two groups.Results The clinical efficacy and efficacy of TCM syndrome in the observation group were su-perior to those in the control group(P<0.05,P<0.01).At 1 month and 2 months after treatment,the24-hour urine pro-tein quantitative and TCM syndrome scores in the observation group were lower than those in the control group(P<0.01);there was no significant difference in Scr,UACR,BUN,and urine red blood cell count between the two groups at 1 month and 2 months after treatment(P>0.05).At1 month and2 months after treatment,the serum tumor necrosis factor-α,hypersen-sitive C-reactive protein,and interleukin-6 levels in the observation group were lower than those in the control group,while CD3 +,CD4 +,and CD4 +/CD8 + were higher than those in the control group(P<0.01).There was no significant differ-ence in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Sanbai Yishen formula is effec-tive in the treatment of chronic nephritis of spleen-kidney deficiency type,which can improve clinical symptoms and renal function,inhibit inflammatory reaction,improve the level of body immunity,and has a certain degree of safety.
Keywords：Chronic nephritisSpleen-kidney deficiency typeTCM syndrome scoreBlood creatinineUrine mi-croalbumin creatinine ratioBlood urea nitrogenTumor necrosis factor-αImmune function
Publication Date：2023-12-22
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 134-139 )