Predictive Value of Serum S100A12 and MPO Levels for Occurrence of Acute Traumatic Coagulopathy in Patients with Severe Craniocerebral Injury
LIU Hong
ZHOU Yaping
LUO Song
Abstract：Objective To investigate the predictive value of serum S100 calc-binding protein A12(S100A12)and myeloperoxidase(MPO)levels for acute traumatic coagulopathy(ATC)in patients with severe craniocerebral injury(STBI).Methods A total of 112 patients with STBI admitted from March 2019 to March 2022 were selected,and 120 healthy sub-jects undergoing physical examination during the same period were selected as control group.Serum S100A12 and MPO levels were determined by enzyme-linked immunosorbent assay.Patients with STBI were divided into ATC group(n =27)and non-ATC group(n =85)according to occurrence of ATC.Receiver operating characteristic(ROC)curve was used to evaluate the predictive value of serum S100A12 and MPO for the occurrence of ATC in patients with STBI.Multivariate Logistic stepwise regression analysis was used to explore the risk factors of the occurrence of ATC in patients with STBI.Results Serum S100A12 and MPO water in the research group were higher than those in the control group(P<0.01),and the levels of ser-um S100A12 and MPO in ATC group were higher than those in non-ATC group(P<0.01).The area under ROC curve(AUC)of the combination of serum S100A12 and MPO for predicting ATC in STBI patients was larger than that predicted by the two indicators alone.Glasgow coma scale score≤3.5 scores,S100A12≥32.46 ng/mL,and MPO≥2.05 ng/mL were independent risk factors for ATC in STBI patients(P<0.05,P<0.01).Conclusion The increase of serum S100A12 and MPO levels is closely related to the occurrence of ATC in STBI patients,which can be used as a predictor of the occurrence of ATC in STBI patients,and the combined prediction efficiency is higher.
Keywords：Craniocerebral injuryS100 calcium-binding protein A12PeroxidaseAcute traumatic coagulopathyGlasgow coma scaleRisk factorsPredictionROC curve
Publication Date：2023-12-22
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 72-76 )