Effect and Immune-inflammatory Mechanism of Wei's Proved Recipes Combined with Diclofenac Sodium in the Treatment of Frozen Periarthritis of Shoulder
LIU Tao
XUE Bin
XI Xiaobing
ZHANG Hao
Abstract：Objective To explore the effect and immune-inflammatory mechanism of Wei's proved recipes combined with Diclofenac Sodium in the treatment of frozen periarthritis of shoulder.Methods A total of 120 patients with frozen peri-arthritis of shoulder treated from January 2020 to June 2022 were selected as the research subjects,and were divided into con-trol group and research group by random number table method,with 60 cases in each group.The control group was treated with Diclofenac Sodium,and the research group was treated with Wei's proved recipes(Shenjin Huoxue Decoction+Bitong lotion)combined with Diclofenac Sodium for three months.The TCM efficacy,TCM syndrome scores,immune-inflammation related indexes[granulocyte-macrophage colony-stimulating factor(GM-CSF),interleukin-10(IL-10),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)],pain factors[prostaglandin E2(PGE2),β-endorphin(β-EP)]and shoulder function-related indexes and occurrence of adverse reactions of the two groups were observed and compared.Results At 3 months after treatment,the total effective rate of the research group was90.00%(54/60),which was higher than that of the control group[75.00%(45/60)](P＜0.05).At 1 and 3 months after treatment,joint pain,swelling,heaviness,chills scores and serum levels of GM-CSF,IL-10,IL-6,TNF-α and PGE2 in the two groups were lower than those before treatment,and lower in the research group than in the control group(P＜0.05).At 1 and 3 months after treatment,passive and active shoulder flexion and abduction motion,MMT score,Constant-Murley score and serum β-EP level in the two groups were high-er than those before treatment,and higher in the research group than in the control group(P＜0.05).There was no signifi-cant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Combined with Di-clofenac Sodium,Wei's proved recipes can relieve inflammation,relieve pain,improve clinical symptoms and shoulder joint function in patients with frozen periarthritis of shoulder,with accurate effect and good safety.
Keywords：Periarthritis of shoulderWei's proved recipesDiclofenac SodiumSyndromeGranulocyte-macrophage colony-stimulating factorInterleukin-10Prostaglandin E2β-endorphin
Publication Date：2023-10-22
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 143-148 )