Application Effect of Naloxone-assisted HFNC in Patients with AECOPD Complicated with Type Ⅱ Respiratory Failure
HAO Taoli
WANG Cuiqin
WANG Xiaoying
HE Wende
JI Jianrui
LI Jiangtao
Abstract：Objective To investigate the application effect of Naloxone-assisted high-flow nasal cannula oxygen thera-py(HFNC)in acute exacerbation of chronic obstructive pulmonary disease(AECOPD)complicated with type Ⅱ respiratory failure(Ⅱ-RF).Methods In total,120 patients with AECOPD complicated withⅡ-RF in our hospital from January 2020 to January 2023 were selected and randomly divided into control group(n =60)and research group(n =60).The control group was given HFNC,and the research group was given Naloxone-assisted HFNC.The therapeutic effect,pulmonary func-tion indexes[forced expiratory volume in the first second(FEV1),FEV1/forced vital capacity(FVC),total lung volume(TLC)],clinical symptoms[acute physiological function and chronic health evaluation scoring System Ⅱ(APACHEⅡ)score,Glasgow Coma Scale(GCS)score],arterial blood gas analysis indexes[arterial partial pressure of oxygen(PaO2),arterial partial pressure of carbon dioxide(PaCO2),arterial oxygen saturation(SaO2)],inflammatory stress indexes[C reac-tive protein(CRP),procalcitonin(PCT),superoxide dismutase(SOD),malondialdehyde(MDA)],progranulin(PGRN),and angiopoietin-2(Ang-2)level before and after treatment were compared between the two groups.The incidence of adverse reactions of the two groups was recorded.Results The total effective rate of the research group was91.67%(55/60),which was higher than that of the control group[76.67%(46/60)](P＜0.05).At 3 and 7 days after treatment,FEV1,FEV1/FVC,TLC,GCS scores,PaO2,SaO2 and SOD levels in the research group were higher than those in the con-trol group,while APACHEⅡ scores,PaCO2 and serum CRP,PCT,MDA,PGRN and Ang-2 levels in the research group were lower than those in the control group(P＜0.05).There was no significant difference in the total incidence of adverse re-actions between the two groups(P＞0.05).Conclusion Naloxone-assisted HFNC in the treatment of AECOPD patients withⅡ-RF can more effectively improve lung function and oxygenation status,reduce inflammation and oxidative stress,and lower serum PGRN and Ang-2 levels,so as to enhance efficacy and have certain safety.
Keywords：Pulmonary diseasechronic obstructiveType Ⅱ respiratory failureNaloxoneHigh-flow nasal cannula oxygen therapyForced expiratory volume in the first secondAcute physiological function and chronic health evaluation sco-ring system ⅡProgranulinAngiopoi
Publication Date：2023-10-22
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 80-85 )