Effects of Yishen Huoxue Decoction on Inflammatory Factors,Hypercoag-ulability and Vascular Endothelial Function in Patients Undergoing Mainte-nance Hemodialysis
LUO Jiapei
XIAO Jingjie
HUANG Lihua
LIAN Jiake
Abstract：Objective To investigate the effects of Yishen Huoxue decoction adjuvant therapy on inflammatory fac-tors,hypercoagulability and vascular endothelial function in patients undergoing maintenance hemodialysis.Methods In to-tal,200 patients with uremia of chronic renal failure treated from June 2019 to December 2022 were selected and divided into two groups according to different treatment methods:observation group(Yishen Huoxue decoction assisted maintenance hemo-dialysis treatment,n =102)and control group(maintenance hemodialysis treatment,n =98).The clinical effect after treat-ment,inflammatory factors,coagulation function and vascular endothelial function before and after treatment,and adverse re-actions during treatment were compared between the two groups.Results After treatment,the total effective rate of observa-tion group(93/102,91.18%)was higher than that of control group(68/98,69.39%)(P＜0.01).After treatment,C reactive protein,tumor necrosis factor-α,interleukin-6,prothrombin time,activated partial thrombin time and endothelin-1 in the two groups were decreased compared with those before treatment,which were lower in the observation group than in the control group.Vulcanized hemoglobin and nitric oxide were higher than those before treatment,which were higher in the ob-servation group than in the control group(P＜0.01).During treatment,there was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion The use of Yishen Huoxue decoction adjuvant therapy for patients undergoing maintenance hemodialysis can improve the level of inflammatory factors,hypercoagulability of the body and vascular endothelial function,with good safety.
Keywords：Renal insufficiencyYishen Huoxue decoctionRenal dialysisC reactive proteinTumor necrosis factor-αProthrombin timeActivated partial thrombin timeSulfurized hemoglobin
Publication Date：2023-09-22
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 118-121 )