Relationship of Changes in Serum TXB2 and CCR7 Levels with Pulmonary Function in Patients with Acute Attack of Bronchial Asthma before and af-ter Treatment
WANG Bo
GAO Maicang
LIANG Jiabin
Abstract：Objective To analyze the relationship between changes in serum thromboxane B2(TXB2),CC chemo-kine receptor 7(CCR7)levels with pulmonary function in patients with acute attack of bronchial asthma(BA)before and af-ter treatment.Methods A total of 203 patients with acute attack of BA admitted from May 2019 to May 2022 were selected.The levels of serum TXB2,CCR7 and pulmonary function of patients with acute attack of BA were compared before and after treatment.According to the degree of pulmonary function injury after treatment,the patients were divided into moderate and severe injury group and mild injury group.The risk factors affecting the exacerbation of pulmonary function injury in patients with acute attack of serum BA were analyzed,and the correlation between serum TXB2,CCR7 and pulmonary function was ex-plored.Results After treatment,the levels of TXB2 and CCR7 in patients with BA acute attack were decreased compared with those before treatment,and the forced vital capacity(FVC),forced expiratory volume in the first second(FEV1),peak expiratory flow(PEF)and FEV1/FVC were increased compared with those before treatment(P＜0.05).Multivariate Logis-tic regression analysis showed that overexpression of serum TXB2 and CCR7 levels was an independent risk factor for the exac-erbation of pulmonary function injury in BA patients(P＜0.05).Among the patients with acute attack of BA,31 cases had moderate or severe impairment of pulmonary function,and 172 cases had mild impairment of pulmonary function.The levels of serum TXB2 and CCR7 in moderate and severe injury group were higher than those in mild injury group(P＜0.01).The lev-els of serum TXB2 and CCR7 in patients with acute attack of BA were negatively correlated with FVC,FEV1,PEF and FEV1/FVC,respectively(P＜0.01).Conclusion After treatment,the levels of serum TXB2 and CCR7 decreased significantly in patients with acute BA attack,which are risk factors for the exacerbation of pulmonary function injury in patients.Close moni-toring of the changes of serum TXB2 and CCR7 levels can provide guidance for clinical treatment.
Keywords：Bronchial asthmaAcute attackThromboxane B2CC chemokine receptor 7Pulmonary functionForced vital capacityPeak expiratory flowRisk factors
Publication Date：2023-09-22
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 53-57 )