Effect of Infusion with Different RBCS:FFP Ratio on Coagulation Func-tion in Patients with Acute Massive Traumatic Hemorrhage
YU Haiyan
XIAO Xin
ZHANG Li
HUANG Yuting
Abstract：Objective To investigate the effects of infusion with different suspended red blood cells(SRBC):fresh frozen plasma(FFP)ratio on coagulation function in patients with acute massive traumatic hemorrhage.Methods In total,100 patients with acute traumatic hemorrhage admitted from June 2019 to February 2023 were divided into different groups ac-cording to the SRBS ︰ FFP ratio of transfusion therapy,including group A(SRBS ︰ FFP≥2 ︰1,n = 32),group B(SRBS︰FFP＜2︰1-1︰1,n =35),and group C(RBCS︰FFP＜1︰1,n =33).The blood product infusion vol-ume,and changes in blood routine and coagulation indexes before and after transfusion were compared among the three groups.Results The FFP infusion volume in group C was higher than that in group B,and higher in group B than in group A(P＜0.05).After blood transfusion,hemoglobin(Hb)of the three groups was higher than that before blood transfusion(P＜0.05),while platelet(PLT)of the three groups was significantly decreased after blood transfusion(P＜0.05);there was no statistical significance in PLT in groups B and C compared with that before blood transfusion(P＞0.05).After blood transfusion,Hb and PLT in groups B and C were higher than those in group A(P＜0.05),but there was no significant differ-ence between group B and group C(P＞0.05).After blood transfusion,thrombin time(TT),prothrombin time(PT)and activated partial thromboplastin time(APTT)in group A were significantly prolonged,D-dimer(D-D)and international nor-malized ratio(INR)were significantly increased,and fibrinogen(FIB)was significantly decreased(P＜0.05).There was no significant difference between group B and group C before transfusion(P＞0.05).After blood transfusion,TT,PT,APTT,D-D and INR in groups B and C were short or lower than those in group A,while FIB was higher than that in group A(P＜0.01),but there was no significant difference between group B and group C(P＞0.05).Conclusion SRBS︰FFP＜2︰1-1︰1 is an appropriate ratio for the treatment of acute massive traumatic hemorrhage,which can help to prevent co-agulation dysfunction and reduce the use of blood products.
Keywords：HemorrhageWounds and injuriesRed blood cell suspensionFresh frozen plasmaBlood transfusionRatioThrombin timeFibrinogen
Publication Date：2023-09-22
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 38-42 )