Effects of Runpo Decoction Combined with Bifidobacterium on Intestinal Microecology in Elderly Patients with Diabetic Constipation

DING Xiaoqing; GAO Yutao; FU Yiling; HAN Yaqing; ZHANG Jing; LU Xudong

doi:10.3969/j.issn.1002-3429.2023.08.030

Abstract：Objective To investigate the effects of Runpo Decoction combined with Bifidobacterium on intestinal mi-croecology in elderly patients with diabetic constipation.Methods A total of 100 elderly patients with diabetic constipation treated from January 2021 to October 2022 were selected and divided into observation group(n =50)and control group(n = 50)according to different treatment methods.The observation group was treated with Runpo Decoction combined with Bifidobacterium,and the control group was treated with Bifidobacterium.The clinical effects at 2 weeks after treatment,TCM syndrome scores,intestinal microecology[bifidobacteria,lactic acid bacteria,Enterobacter,diamine oxidase(DAO),D-lactic acid,urinary lactulose-mannitol ratio(L/M)]and PI3K/Akt signaling pathway related proteins of peripheral blood mononuclear cells before and at 2 weeks after treatment,adverse reactions during treatment and recurrence at 4 weeks after drug discontinuation were compared between the two groups.Results Finally,49 cases in the observation group and 48 cases in the control group completed the study.At 2 weeks after treatment,the total effective rate of the observation group was 91.84%(45/49),whichwashigherthanthatofthecontrolgroup[75.00%(36/48)](P＜0.05).At 2 weeks after treat-ment,difficulty in defecation,defecation interval,stool characteristics,incomplete defecation score,enterobacter,DAO,D-lactic acid,L/M,PI3K and Akt protein of peripheral blood mononuclear cells in the two groups were lower than those be-fore treatment,and lower in the observation group than in the control group.Lactobacillus and Bifidobacterium in the two groups were higher than those before treatment,and higher in the observation group than in the control group(P＜0.01).There was no significant difference in the total incidence of adverse reactions between the two groups during treatment and the recurrence rate at 4 weeks after drug withdrawal(P＞0.05).Conclusion Runpo Decoction combined with Bifidobacterium has a significant effect in the treatment of elderly patients with diabetic constipation,which can improve clinical symptoms and regulate intestinal microecology,with good safety.This may be related to the regulation of PI3K/Akt signaling pathway.