Changes and Clinical Significance of Serum ICAM-1,IL-17,and IL-8 in Children with Acute Exacerbation of Bronchial Asthma
PENG Dingyu
LAI Chunlian
WEI Jiamei
LIU Qianhua
BAN Jian
PEI Hehuan
Abstract：Objective To analyze the changes and clinical significance of serum cell adhesion molecule-1(ICAM-1),interleukin-17(IL-17)and interleukin-8(IL-8)in children with acute exacerbation of bronchial asthma.Meth-ods In total,95 children with acute exacerbation of bronchial asthma treated from February 2019 to February 2022 were se-lected as the observation group,and 99 healthy children undergoing physical examination during the same period were selected as the control group.Serum levels of ICAM-1,IL-17 and IL-8 were compared between the two groups,and were recorded in children with different disease conditions.Multivariate Logistic regression analysis was used to investigate the risk factors af-fecting asthma control in children.Results The levels of ICAM-1,IL-17 and IL-8 in the observation group were higher than those in the control group(P＜0.01).The levels of serum ICAM-1,IL-17 and IL-8 in children with more severe disease were also gradually increased(P＜0.05).Multivariate Logistic regression analysis showed that serum ICAM-1,IL-17 and IL-8 levels were independent risk factors affecting the control level of bronchial asthma in children(P＜0.05,P＜0.01).Conclu-sion The levels of serum ICAM-1,IL-17 and IL-8 in children with acute exacerbation of bronchial asthma are significantly increased,which has an important relationship with the occurrence and development of the disease.
Keywords：AsthmaChildCell adhesion molecules-1Interleukin-17Interleukin-8Asthma controlRisk fac-torsSeverity of disease
Publication Date：2023-08-22
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 89-93 )