Effect of Carbon Dioxide Mask on Blood Gas Analysis and Cerebral Oxy-gen Metabolism in Patients with Respiratory Alkalosis after Tracheotomy

LIANG Baoping; LIU Kaiwen

doi:10.3969/j.issn.1002-3429.2023.08.012

Abstract：Objective To investigate the effects of carbon dioxide mask on blood gas indexes and cerebral oxygen me-tabolism in patients with respiratory alkalosis after tracheotomy.Methods Fifty patients with respiratory alkalosis after trach-eotomy treated from January 2020 to January 2023 were selected and divided into observation group(n =25)and control group(n =25)according to intervention methods.The observation group used carbon dioxide mask fixed on the face for abdominal breathing,and the control group used traditional paper bag covering the mouth and nose for abdominal breathing.The clinical effect and the time of complete remission of symptoms were compared between the two groups.Blood gas indexes[arterial par-tial pressure of carbon dioxide(PaCO2),base excess extracellular fluid(BEecf),actual bicarbonate(AB),total carbon di-oxide],circulation indexes[mean arterial pressure(MAP),heart rate(HR),respiratory rate(RR)],cerebral oxygen me-tabolism indexes[cerebral arterio-venous oxygen content difference(Da-jvO2),cerebral oxygen uptake rate(CERO2)],and oxidative stress indexes[myeloperoxidase(MPO),malondialdehyde(MDA),superoxide dismutase(SOD)]levels before tracheotomy(T1),at 10 min after tracheotomy(T2),at 30 min after tracheotomy(T3),and immediately after operation(T4)were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group(P＜0.01).The time to complete remission of symptoms in the observation group was(32.27±10.62)min,which was shorter than that in the control group[(154.23±40.16)min](P＜0.01).PaCO2,BEecf,AB,total carbon dioxide and SOD in the two groups were significantly lower at T2 than at T1,and higher at T3-T4 than at T2,which were lower at T3-T4 than at T1 in the control group,and higher at T3-T4 in the observation group than in the control group(P＜0.05).MAP,HR,RR,Da-jvO2,CERO2,MPO and MDA in the two groups were significantly higher at T2 than at T1,and lower at T3-T4 than at T2,which were higher at T3-T4 than at T1 in control group,but lower at T3-T4 in the ob-servation group than in the control group(P＜0.05).Conclusion The use of carbon dioxide mask in patients with respirato-ry alkalosis after tracheotomy can improve the clinical effect,accelerate the improvement of clinical symptoms,promote more stable blood gas circulation,correct the abnormal state of cerebral oxygen metabolism,and help alleviate the oxidative stress injury of the body.