Effect of Non-convulsive Electroconvulsive Therapy Combined with Agome-latine in Antidepressant Treatment
XU Yanyan
QIAO Yunshuan
LI Li
NIU Xingzhen
LI Jing
LIU Wei
Abstract：Objective To observe the effect of non-convulsive electroconvulsive therapy(MECT)combined with Ag-omelatine on patients with depression.Methods A total of 104 patients with depression admitted from June 2021 to June 2022 were divided into observation group(n =52)and control group(n =52)according to different treatment methods.The control group was treated with Agomelatine,and the observation group was treated with MECT combined with Agomelatine.The course of treatment was 4 weeks.The therapeutic effects,Hamilton depression scale(HAMD-24)score,Pittsburgh sleep quality index(PSQI)score,non-suicidal self-injury(NSSI)behavior,C-reactive protein(CRP),interleukin-6(IL-6),interleukin-18(IL-18),tumor necrosis factor-α(TNF-α)level and adverse reactions before and after treatment of the two groups were com-pared.Results At 4 weeks after treatment,the total effective rate of observation group was higher than that of control group[(92.31%,48/52)vs.(75.00%,39/52)](P＜0.05).HAMD-24 score,PSQI score,NSSI behavior pattern,frequency of NSSI behavior and levels of CRP,IL-18,TNF-α and IL-6 in the two groups were lower or less at 2 weeks and 4 weeks after treatment,and lower or less at 4 weeks after treatment,as compared with those at 2 weeks after treatment(P＜0.05).HAMD-24 score,PSQI score,NSSI behavior pattern,frequency of NSSI behavior,and CRP,IL-18,TNF-α and IL-6 levels in observation group were lower or less than those in control group at 2 weeks and 4 weeks after treatment(P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion MECT combined with Agomelatine can regulate the levels of inflammatory factors in patients with depression,reduce the degree of de-pression and self-injury behavior,and improve sleep quality,and the effect is reliable with fewer adverse reactions.
Keywords：DepressionNon-convulsive electroconvulsive therapyAgomelatinePittsburgh sleep quality indexSelf-injury behaviorC reactive proteinTumor necrosis factor-αDrug toxicity
Publication Date：2023-07-22
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 144-148 )