Diagnostic Value of sdEEG Combined with Serum Glutamine and IGF-1 Detection in Children with Epilepsy
SHI Honglei
WANG Xuejing
QI Fengqin
ZHONG Fangfang
Abstract：Objective To analyze the application value of sleep-deprivation electroencephalogram(sdEEG)com-bined with serum glutamine and insulin-like growth factor-1(IGF-1)in children with epilepsy.Methods A total of 86 chil-dren with suspected epilepsy admitted to hospital from March 2020 to March 2022 were selected as observation subjects,all of whom underwent sdEEG examination.The detection of epilepsy by sdEEG was analyzed,the detection rate of epileptic dis-charge and the time of epileptic discharge by sdEEG in children of different ages were compared,and the serum glutamine and IGF-1 levels were compared between epileptic and non-epileptic children.The diagnostic value of sdEEG combined with serum glutamine and IGF-1 in children with epilepsy was evaluated by receiver operating characteristic(ROC)curve.Results Of the 86 children with suspected epilepsy,74(86.05%)were diagnosed with epilepsy.Sixty-six patients with epilepsy and20 patients without epilepsy were diagnosed by sdEEG,and the detection rate was 76.74%.The detection rate of epileptic dis-charge in children aged 1 to 3 years was the highest by sdEEG,which was significantly higher than that in children aged 4 to 7 years and＞7 years(P＜0.05).The proportion of epileptic discharge in sleep period was significantly higher than that in awake period and sleepiness period by sdEEG(P＜0.01).Serum levels of glutamine and IGF-1 in epileptic children were significantly lower than those in non-epileptic children(P＜0.01).The area under the ROC curve(AUC)of sdEEG,serum glutamine and IGF-1 in the diagnosis of childhood epilepsy were 0.849,0.740 and 0.804,respectively,and the AUC of the combined detection of the three was 0.735.Conclusion sdEEG is appropriate for the detection of epilepsy in children of all ages.sdEEG,serum glutamine and IGF-1 are of high value in the diagnosis of epilepsy in children.
Keywords：EpilepsyChildSleep-deprivation electroencephalographySleep stageInsulin-like growth factor-1GlutamineReceiver operating characteristic curveDiagnosis
Publication Date：2023-07-22
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 134-137 )