Effects of Hemoperfusion Combined with Hemodialysis on Clinical Effica-cy,β2-MG and PTH of Uremic Pruritus

GAO Shuang; YE Shengmei; TONG Ruihua

doi:10.3969/j.issn.1002-3429.2023.07.023

Abstract：Objective To analyze the effects of hemoperfusion combined with hemodialysis on the clinical efficacy,β2-microglobulin(β2-MG)and parathyroid hormone(PTH)of uremic pruritus(UP).Methods In total,201 patients with UP treated in our hospital from December 2021 to October 2022 were selected,and according to different treatment plans,they were divide into control group(n =98)and research group(n =103).The control group was treated with hemodialysis,and the research group was treated with hemoperfusion combined with hemodialysis.The clinical efficacy,inflammatory factors[interleukin-1(IL-1),interleukin-6(IL-6),procalcitonin(PCT)],renal function indexes[serum urea nitrogen(BUN),creatinine(Scr),β2-MG],calcium and phosphorus metabolism indexes(serum phosphorus,calcium,PTH)and recurrence rate of the two groups were compared.Results The total effective rate was 91.26%(94/103)in the research group and 79.59%(78/98)in the control group(P＜0.05).After treatment,the levels of IL-1,IL-6,PCT,BUN,Scr,β2-MG,PTH and serum phosphorus in the two groups were lower than those before treatment,and lower in the research group than in the control group(P＜0.05).After treatment,serum calcium in the two groups was higher than that before treatment,and higher in the research group than in the control group(P＜0.05).The recurrence rate of the research group was lower than that of the control group[5.83%(6/103)vs.43.88%(43/98)](P＜0.05).Conclusion Hemoperfusion combined with hemodialysis is effective in the treatment of UP,which can improve the inflammatory state,reduce the levels of PTH and β2-MG,and effectively remove large and medium-sized metabolites in the body of patients.