Changes in Oxygen Free Radicals,Myocardial Damage-related Factors and Inflammatory Factors in Patients after Off-pump Coronary Artery Bypass Transplantation
WU Guanghang
LYU Jing
WANG Junhua
LI Huajun
Abstract：Objective To investigate the changes of oxygen free radicals,myocardial damage-related factors and in-flammatory factors in patients after off-pump coronary artery bypass grafting(OPCABG).Methods In total,93 patients with coronary heart disease(CHD)treated from October 2019 to October 2022 were selected and divided into the OPCABG group(receiving OPCABG,n =51)and the on-pump coronary artery bypass grafting(CABG)group(receiving CABG,n =42)ac-cording to the surgical plan.The surgery-related factors,and the levels of serum oxygen free radicals,myocardial damage-related factors and inflammatory factors before and at 2,6 and 24 h after treatment were compared between the two groups.Results The duration of operation,length of ICU stay,duration of tracheal intubation,and length of hospitalization in the OPCABG group were shorter than those in the on-pump CABG group,and the blood transfusion volume at 24 h after operation was less than that in the on-pump CABG group(P＜0.01).After treatment,the level of superoxide dismutase(SOD)de-creased first and then increased,and the level of malondialdehyde(MDA)increased first and then decreased;the changes of SOD and MDA levels in OPCABG group were significantly smaller than those on-pump CABG group(P＜0.05,P＜0.01).With the extension of treatment time,the level of myocardial creatine kinase isoenzyme(CK-MB)in the two groups was grad-ually increased,and the level of CK-MB in OPCABG group was lower than that on-pump CABG group at 2,6 and 24 h after surgery(P＜0.05,P＜0.01).After treatment,the level of cardiac troponin I(cTnI)in the two groups increased initially and then decreased,and the cTnI level in the OPCABG group was lower than that on-pump CABG group at 2,6 and 24 h after surgery(P＜0.05,P＜0.01).With the prolongation of treatment,the levels of interleukin-6(IL-6),interleukin-8(IL-8)and interleukin-10(IL-10)in the two groups were gradually decreased,which were lower in OPCABG group than in on-pump CABG group at 2,6 and 24 h after surgery(P＜0.05,P＜0.01).Conclusion OPCABG can effectively reduce the levels of serum oxygen free radicals and inflammatory factors in patients with CHD,and can alleviate myocardial injury,which is bet-ter than that of on-pump CABG.
Keywords：Coronary heart diseaseCoronary artery bypass graftingoff-pumpSuperoxide dismutaseMalondialde-hydeMyocardial creatine kinase isoenzymeTroponin IInterleukin-6Interleukin-8
Publication Date：2023-07-22
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 86-90 )