Efficacy of Spleen Aminopeptide Combined with Vitamin A and E in the Treatment of Children with Recurrent Respiratory Tract Infection and its Immune Function

WANG Wei; LI Yu-xue; HU Min

doi:10.3969/j.issn.1002-3429.2019.03.006

Abstract：Objective To explore the clinical effect of spleen aminopeptide combined with vitamin A and E and their effect on the immune function of children with recurrent respiratory tract infection (RRTI). Methods A total of 130 children with RRTI admitted to our hospital from December 2016 to January 2018 were randomly divided into observation group (n=67) and control group (n=63). Both groups were given conventional treatment such as anti-infection, abatement of fever, cough relief and nutrition enhancement during acute infection. In the meantime, the control group was treated with vitamin A and E. On the basis of the control group, the observation group was supplemented with Spleen Aminopeptide Oral Solution. Both groups were treated for 2 months. The clinical efficacy was observed, and the changes of T lymphocyte subsets and immunoglobulin levels were detected. In addition, the occurrence of adverse reactions was recorded. Results The total clinical effective rates of the observation group and the control group were 91.04％ (61/67) and 73.02％ (46/63) respectively, and the difference was statistically significant (χ2=7.239, P=0.013). Compared with those before treatment, the levels of CD3+, CD4+, CD4+/CD8+, IgG, IgM and IgE in the observation group were increased while the levels of CD8+ were decreased significantly after treatment (P＜0.05). Compared with the control group, the levels of CD3+, CD4+, CD4+/CD8+, IgG, IgM and IgE in the observation group were increased significantly and the levels of CD8+ were decreased significantly after treatment (P＜0.01). There were no obvious adverse reactions during the treatment. Conclusion Spleen aminopeptide combined with vitamin A and E in the treatment of children with RRTI can effectively improve the clinical efficacy and the body's immunity, which is, therefore, conducive to the prognosis of children.