Clinical Features of Reversible Splenial Lesion Syndrome: a Report of Five Cases
LIU Zhao
ZHU Ling
HUO Fa-rong
SHAO Shao-ju
ZHANG Xiao-yan
YIN Rong
Abstract：Objective To explore the clinical features of reversible splenial lesion syndrome (RESLES). Methods The clinical data of 5 cases with RESLES treated in our hospital from January 2016 to December 2017 were retrospectively analyzed. Results All 5 cases had acute onset, and the causes included high altitude sickness, severe hypoglycemia, severe infections or acute hepatic injury respectively. Their prodromal symptoms included fe-ver, abdominal pain, abdominal distension, diarrhea, cough and difficulty in breathing. Then these patients presen-ted with neurological symptoms including headache, nausea, vomiting, and disturbance of consciousness. Magnetic resonance imaging of the brain showed a marked hyperintensity in the splenium of the corpus callosum. The 5 cases were ultimately diagnosed with RESLES. Under effective etiological and symptomatic treatment ( such as controlling blood sugar levels, anti-infective treatment or liver protective therapy) , their clinical symptoms were markedly re-lieved. At 6-month follow-up, all of the five patients had favorable prognosis. Conclusion The pathogenesis of RESLES is complicated and clinical manifestations are non-specific. Reversible focal lesion in the splenium of the corpus callosum is the main diagnostic feature. The majority of patients suffering from this disease appear to achieve full recovery after they receive timely symptomatic treatment.
Keywords：Reversible splenial lesion syndromeMagnetic resonance imagingClinical features
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 102-105 )