Analysis of Prognostic Factors of Brain Glioma

BAI Qing-ling; HU Chang-wei; PENG Ying-ying; YAO Yu-fang; WANG Xi-rui; ZHAO Zhi-huang; HAN Yong-gang

doi:10.3969/j.issn.1002-3429.2018.07.025

Abstract：Objective To analyze prognostic factors in patients with brain glioma, thereby providing theoret-ical basis for the development of more accurate treatment plan in clinical practice. Methods Clinical data and fol-low-up data of 93 cases of brain gliomas in Canzhou Central Hospital from January 2013 to June 2016 were retrospec-tively analyzed, to explore related prognostic factors. Results The incidence of this disease was slightly higher in males than in females. The main clinical symptoms included sudden limb twitching, headache, fatigue, vomiting, altered visual acuity, and language communication disorders, with a high degree of malignancy and poor prognosis. They were followed up until October 2017, and the 2-year survival rate of this group was 54. 84% . According to uni-variate analysis of brain glioma in 93 cases, age, tumor grade, preoperative KPS score, operation methods, postoper-ative chemoradiotherapy, postoperative use of temozolomide ( TMZ) treatment were the prognostic factors of patients with brain glioma. Multivariate Cox regression analysis showed that elderly patients ( aged 60 or older) , high grade tumors, partial tumor resection and preoperative KPS score <70 points, no postoperative chemoradiotherapy and TMZ<4 courses after surgery were independent risk factors for the prognosis of glioma patients. Conclusion Early symptoms of brain glioma are not typical, with a high degree of malignancy and poor prognosis. The older patients, the higher tumor grade, partial tumor resection, lower preoperative KPS score contribute to worse prognosis of TMT patients. Postoperative chemoradiotherapy coupled with multiple courses of TMT treatment can prolong the survival of patients.