Analysis of the Correlation of Insulin Resistance Index to Serum Betatrophin and Lp-PLA2 in Coronary Heart Disease Patients
HAN Wei
WEI Fang-jing
Abstract：Objective To investigate the correlation of insulin resistance ( IR) index to serum recombinant Betatrophin and Lp-PLA2 in coronary heart disease ( CHD) patients. Methods A total of 212 CHD patients admit-ted to our hospital from May 2015 to May 2017 were divided into IR group ( n＝133) and non-IR group ( n＝79) based on presence of IR. According to the HOMA-IR level, they were divided into <3. 0 group (n＝84), 3. 0-5. 0 group (n＝81), and ≥5. 0 group (n＝47). Clinical data, glucolipid metabolic indexes, serum Betatrophin, and Lp-PLA2 level differences were compared between two groups. Correlation between serum Betatrophin, Lp-PLA2 and HOMA-IR were also analysed. Results As compared with non-IR group, IR group showed higher BMI, larger waist-hip ratio, higher LDL-C and hsCRP, and lower serum HDL-C (P<0. 01). In addition, FPG, FPI, HOMA-IR, HOMA-βand Lp-PLA2 were significantly increased, whereas Matsuda index and serum recombinant Betatrophin were decreased remarkably (P<0. 05 or P<0. 01). BMI, waist-to-hip ratio and serum HDL-C, LDL-C and hs-CRP levels differed significantly in HOMA-IR 3. 0-5. 0 group and HOMA-IR ≥5. 0 group, as compared with those in HOMA-IR<3. 0 group (P <0. 05). Patients with larger HOMA-IR value showed higher FPG and FPI, larger HOMA-β value, and higher Lp-PLA2, but lower Matsuda index and serum Betatrophin (P<0. 05). Conclusion Serum Betatrophin and Lp-PLA2 level were closely related to the IR indexes in CHD patients.
Keywords：Coronary diseaseInsulin resistanceBetatrophinLp-PLA2Correlation
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 82-86 )