Effects of Preemptive Analgesia with Oxycodone on Postoperative Analgesia and the Level of Inflammatory Cytokines in Patients with Closed Abdominal Trauma
ZHANG Jin-li
XIAO Fang
BAI Yan-hui
DAI Zhi-qiang
YU Hong-lian
WANG Shuo
Abstract：Objective To observe the effect of preemptive analgesia with oxycodone on postoperative analge-sia and levels of inflammatory cytokines in patients undergoing emergency laparotomy due to closed abdominal trau-ma. Methods A total of 60 cases who underwent emergency laparotomy under general anesthesia after admission to The First Central Hospital of Baoding were randomly divided into observation group and control group, with 30 cases in each group, according to the random number table. Patients in observation group were injected intravenously with 0. 1 mg/kg oxycodone 10 min before induction of anesthesia, and those in control group were given 10 ml 0. 9% sa-line in the meantime. VAS was recorded at different time points, including awaking time immediately after surgery, as well as at 2, 6, 12, and 24 h after surgery. The levels of interleukin-6 (IL-6), interleukin 10 (IL-10) and tumor necrosis factor-α (TNF-α) were measured by ELISA in 10 min before intravenous injection of oxycodone or 0. 9% saline (TI), immediately after surgery (T2), 6 h (T3),12 h (T4), and 24 h (T5) after surgery. Results VAS was significantly lower in observation group immediately after surgery, and at 2, 6 and 12 h after surgery, and there were significant differences ( P<0. 01) . Serum levels of IL-6 at three time points ( T3, T4 and T5) after surgery were significantly higher than those at T1 and T2 ( P<0. 05) , and serum levels of IL-6 in observation group were significantly lower than those in control group ( both P<0. 01) . IL-10 level at T3 and T4 was significantly higher in both groups ( P<0. 05) , and serum IL-10 in observation group was significantly higher than control group ( both P<0. 01) . Serum TNF-α concentration at T4 and T5 was significantly higher in both groups than that at T1 ( P <0. 05). In addition, the level of TNF-α in observation group was significantly lower than that in control group at T4 and T5 (both P<0. 05). Conclusion In patients receiving emergency laparotomy due to closed abdominal trauma, preemptive analgesia with oxycodone can inhibit the release of inflammatory factors, and reduce the central and pe-ripheral nervous system sensitivity, thereby reducing postoperative pain and promoting rehabilitation.
Keywords：Abdominal injuriesOxycodoneAnesthesia and analgesiaInflammatory factors
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 37-41 )