Effect of Dexmedetomidine Combined with Ropivacaine on Thoracic Paravertebral Nerve Block after Unilateral Thoracotomy and the Satisfaction of Analgesia
WANG Fu-gang
PENG Yi
WANG Xue-ran
LU Jian-bo
WEI Zhi-hui
WANG Zhi-cun
Abstract：Objective To investigate the effect of dexmedetomidine combined with ropivacaine on thoracic paravertebral nerve block ( TPVB) after unilateral thoracotomy and the satisfaction of analgesia. Methods A total of 87 patients who underwent unilateral thoracotomy in our hospital from January 2016 to March 2017 were randomly di-vided into the observation group ( n ＝47) and the control group ( n ＝40 ) , according to alternate medical record number. The control group was treated with 30 ml 0. 35% ropivacaine for TPVB, whereas the observation group was treated with 1 μg/kg dexmedetomidine injection+30 ml 0. 35% ropivacaine for TPVB. The effect of paravertebral block,recovery time, the hemodynamic changes at different time points [ at the time of sedation after entering operat- ing room( T0) , at 15 min after thoracic paravetebral injection ( T1) , immediately after tracheal intubation ( T2) , 5 min after skin incision ( T3) and before postoperative extubation( T4) ] , visual analogue score( VAS) at 6, 12, 24, and 48 h after surgery and adverse reactions were recorded and compared between the two groups. Results There were no significant differences between the two groups regarding the onset time of vertebral block, the fixation time of the block plane, and recovery time (P>0. 05). Compared with the control group, mean arterial pressure (MAP) and heart rate ( HR) in T1-T4 in the observation group were decreased significantly ( P<0. 05) . Changes of MAP and HR levels in T1-T4 showed no significantly differences in observation group ( P>0. 05) , whereas those in T2-T4 in control group ( P<0. 05) . The VAS scores at 6, 12, 24 and 48 h after surgery were significantly lower in the observation group than in the control group ( P<0. 05) . Conclusion The effect of dexmedetomidine com-bined with ropivacaine on TPVB after unilateral thoracotomy was preferable, and postoperative analgesia was satisfac-tory. It helps to maintain the hemodynamic stability of the body, with minimal adverse reactions. Thus, it is worthy of clinical application.
Keywords：Thoracic paravertebral nerve blockDexmedetomidineRopivacaineAnesthesia and analgesia
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 29-33 )