Changes of Trace Elements Levels in Patients with Maintenance Hemodialysis at Different Ages and Their Effects on Survival Quality

CHEN Yong; HUANG Qiao-mu; TAN Hong-jin; GE Liang; LIU Na-li

doi:10.3969/j.issn.1002-3429.2018.06.029

Abstract：Objective To explore the changes of trace elements levels in patients with maintenance hemodi-alysis ( MHD) at different ages and their effects on survival quality. Methods A total of 100 patients with MHD were selected as the observation group, which was subdivided into the elderly group (≥65 years old) and the young and middle-aged group ( <65 years old) . In the meantime, another 50 healthy examiners were selected as the con-trol group. The changes of trace elements levels were observed among groups, and short-form health status question-naire (SF-36) was recorded. The correlation between MHD and trace elements was explored, and the levels of trace elements and the influencing factors were analyzed in patients with different SF-36 scores. Results The levels of i-ron and zinc were lower whereas the levels of selenium and copper were higher in the observation group, as compared with those in the control group (P<0. 05). Compared with the young and middle-aged group, the levels of iron and zinc and all-dimension scores of SF-36 scale were significantly lower whereas the levels of selenium and copper were significantly higher in the elderly group ( P<0.05 ) . Pearson correlation analysis showed that iron and zinc contents were negatively correlated with age ( r= -0 .124 , P=0.004;r= -0.452 , P=0.000 ) , and selenium and copper were positively correlated with age ( r=0. 232 , P=0.012; r=0.132 , P=0.010 ) . With the decrease of SF-36 scores, the levels of iron and zinc in the body of MHD patients were decreased gradually while the levels of selenium and copper were increased gradually (P<0.05). Multiple linear regression analysis revealed that iron, zine, seleni-um and copper were independent influencing factors of SF-36 scores. Conclusion The changes of trace elements in MHD patients at different ages are closely associated with the survival quality.