Correlation Study on CAT Score,Lung Function,Interleukin-17 and Interleukin-8 in Exhaled Breath Con-densate at Different Periods of COPD
LIU Dong
LIN Zhi-feng
XU Xi-lin
LU De-gan
Abstract：Objective To investigate the correlation of CAT score and lung function to interleukin-17 (IL-17) and interleukin-8 (IL-8) in exhaled breath condensate (EBC) in patients with chronic obstructive pulmonary disease (COPD) at different periods. Methods Eighty-one acute COPD exacerbations (AECOPD) patients were selected as the study group,whereas 78 healthy people were taken as the control group. After 14 d of regular anti-in-fective and symptomatic treatment, symptoms of AECOPD patients at acute exacerbation period was significantly re-lieved,which was referred to as a stable period. The levels of IL-17 and IL-8 in EBC and lung function were meas-ured and compared between the AECOPD group, stable COPD group and control group. The relationship of IL-17 and IL-8 in EBC to CAT score and the forced expiratory volume (FEV) in one second/predicted value ratio (FEV1% pred) in AECOPD group and stable group was analyzed. The relationship of CAT score and FEV1% pred in AECOPD group and stable group was analyzed. The relationship between the improvement in IL-17 and IL-8 in EBC as well as in CAT score from acute exacerbation to stable phase was analyzed and the improvement in FEV1% pred from acute exacerbation to stable phase was analyzed. Results The levels of IL-8 and IL-17 in EBC of AECOPD group were significantly higher but the levels of FEV1% pred were significantly lower than those in stable group(P<0.05). The levels of IL-8 and IL-17 in EBC were significantly higher and the levels of FEV1% pred were remarkably lower in AECOPD group and stable group than in control group(P<0.05). There was a positive correlation of CAT score to IL-17 and IL-8 in the EBC of AECOPD group and stable group. Additionally,there was a positive correlation of the improvement of IL-8 and IL-17 in EBC and CAT score to FEV1% pred from acute exacerbation period to stable period (P<0.05). Conclusion In COPD patients,higher level of IL-17 and IL-8 in EBC and higher CAT score contributes to more serious disease and poorer life quality. The lung functional indicators, IL-17 and IL-8 in EBC, and CAT score can be objective and noninvasive in the evaluation of severity and life quality of COPD patients.
Keywords：Pulmonary diseasechronic obstructivePulmonary functionExhaled breath condensateIn-terleukin 17Interleukin 8
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 82-86 )