Expression and Prognostic Value of AKT1 and AKT2 in Patients with Glioblastoma
CHANG Liang
WANG Xin
TAN Chun-lei
ZHANG Xue-xin
Abstract：Objective To investigate the expression and prognostic value of AKT1 and AKT2 in patients with glioblastoma (GBM).Methods AKT1 and AKT2 expression was assessed by immunohistochemistry in 93 cases of GBM (tumor group) and 20 normal brain tissues (control group) which were obtained intraoperatively in patients with cerebral vascular malformation.Overall survival (OS) was evaluated graphically with Kaplan-Meier curves.The multivariate analysis for OS was performed using Cox regression analysis.Results The positive expressions of AKT1 and AKT2 in tumor group were 74.19％ (69/93) and 67.74％ (63/93) respectively,which were significantly higher than those in control group (5％,1/20;15％,3/20).Kaplan Meier method showed patients with positive AKT1 or AKT2 expression had significantly shorter OS relative to those with negative expression,indicating significant differences (P ＜ 0.05).The multivariate Cox regression analysis revealed that extent of surgical resection,adjuvant treatment,and AKT1 and AKT2 expression were independent risk factors for OS (P ＜ 0.05) in patients with GBM.Conclusion The expression of AKT1 and AKT2 may be associated with prognosis of GBM,and could be considered as significant prognostic indicators.
Keywords：GlioblastomaAKT1 proteinAKT2 proteinPrognosis
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 96-99 )