Analysis of Severe Mental and Behavioural Disorder Due to Long-term Oral Administration of Phenytoin Sodium
YU Li-dan
LI Hai-jiang
AN Yi-jun
YANG Dan
CHEN Tao
Abstract：Objective To investigate the clinical manifestations,diagnosis and treatment of Phenytoin sodium poisoning.Methods A retrospective analysis was performed on clinical data of 1 patient with severe mental and behavioral disorder caused by long-term use of oral Phenytoin sodium in our hospital.Results The patients was admitted in emergency due to unsteady gait,diplopia,auditory hallucinations for three and a half months,and intermittent consciousness disorders for 2 months.He was diagnosed with epilepsy 10 years ago,which was under control by long-term oral administration of phenytoin of 100 mg three times a day.The dosage was increased to 200 mg three times a day by himself 3 years ago when symptoms were aggravated.Phenytoin was withdrawn when he developed neurological symptoms.The dosage was increased to 300 mg three times a day due to epileptic seizures.According to the clinical symptoms,signs and medical examination results,he was diagnosed as having severe mental & behavioral disorder caused by Phenytoin poisoning.Thus,Phenytoin was discontinued,and he was treated with Sodium Valproate and Topiramate,and given supportive treatment,such as neurotrophic drugs,diuretic,and folic acid.As psychiatric symptoms were relieved,he was discharged from hospital.Conclusion Given non-specific symptoms of Phenytoin sodium poisoning in clinical settings,it is key to raise awareness and monitor plasma concentration regularly,thereby avoiding or reducing misdiagnosis.
Keywords：PoisoningEpilepsytonic-clonicPsychotherapy drugs
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 89-91 )