Analysis of Misdiagnosis of One Case of Multiple System Damage Due to Intoxication Induced by Low-dose Clozapine
LIN Jin-huang
HONG Chun-yong
WU Xin-yu
ZENG You-fu
LU Wu-sheng
Abstract：Objective To discuss clinical features and treatment measures of low-dose Clozapine intoxication.Methods The clinical data of a case suffering grave intoxication induced by low-dose Clozapine and misdiagnosed in our hospital were retrospectively analyzed.Results The patient was admitted to hospital for coma with mouth convulsion and salivation for 4 h and schizophrenia for ten years.He received long-term Clozapine (50 mg,2times/d) treatment on a regular basis.Brain MRI was unremarkable,however,chest CT showed increased markings in both lungs.Additionally,intracranial pressure monitored by lumbar puncture was 300 mmHg.Thus,he was initially misdiagnosed with status epilepticus,intracranial infection and pulmonary infection.The patient waking up after symptomatic treatment stated that he had taken Clozapine 100 mg before onset.The final diagnosis was Clozapine intoxication and the patient gradually improved and was discharged after comprehensive treatment including diuretics,reducing intracranial pressure,cholinolytics,tracheal intubation and assisted mechanical ventilator.Conclusion Given association between low-dose Clozapine and multisystem damage,heightened perceptions of the disease,comprehensive analysis and timely medical examinations are key to reducing misdiagnosis.
Keywords：PoisoningClozapineMisdiagnosisStatus epilepticus
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 26-29 )