Effect of Different Duration of Oxygen Therapy on Short-term Memory in Patients with Schizophrenia after Modified Electroconvulsive Therapy

ZHANG Guo-ling; YU Bin; ZHANG Hong; GAO Shu-ying

doi:10.3969/j.issn.1002-3429.2018.02.028

Abstract：Objective To invstigate effect of different duration of oxygen therapy on short-term memory(STM) in pa-tients with schizophrenia after modified electroconvulsive therapy (MECT). Methods A total of 160 patients with schizo-phrenia were divided into control group (n=40),experiment group 1 (n=40), experiment group 2 (n= 40) and experi-ment group 3 (n= 40). All the patients received MECT. After MECT,experiment group 1,2 and 3 received oxygen therapy for 20 min,40 min,and 60 min respectively,while control group did not received oxygen therapy. Positive and negative syn-drome scale(PANSS) scores before and at 24h and in 4 weeks after treatment,and memory quotient(MQ) values before and at 24 h and in 1,2 and 4 weeks after treatment were observed and compared in four groups. Results There were significant differences in PANSS scores at different times in each group (P<0.05). Compared with those before treatment in the same group,PANSS scores at 24h and in 4 weeks after treatment were significantly lower in each group,and the PANSS score in 4 weeks after treatment was significantly lower than that at 24h after treatment in the same group(P<0.05). There were signif-icant differences in MQ values at different times in each group(P<0.05). Compared with that before treatment in the same group,MQ value at 24h after treatment was significantly lower in each group(P<0.05). Compared with those at 24 h after treatment,MQ value was significantly increasing in 2 weeks after treatment in control group,while the value was significantly increasing in 1 week after treatment in experiment group 1(P<0.05). In experiment group 2,MQ value was significantly in-creasing in 1 week after treatment compared with that at 24h after treatment, and the values in 1,2 and 4 weeks after treat-ment were significantly increased compared with those before treatment(P<0.05). In experiment group 3,MQ value was in-creasing in 1 week after treatment compared with that at 24h after treatment, and the value was significantly increased at 2 weeks after treatment compared with those before treatment(P<0.05). There were significant differences in MQ values in 1, 2 and 4 weeks after treatment in each group (P<0.05),and the MQ values in experiment group 2 were significantly higher than those in control group and experiment group 1(P<0.05). Conclusion A continuous oxygen inhalation for 40 min may effectively improve STM dysfunction after MECT in patients with schizophrenia.