Effects of MCP-1,TNF-α, IL-6 and Hs-CRP Levels in Peripheral Blood on Function of Vascular Access in Treat-ment of Patients with Maintenance Hemodialysis
ZHOU Dan
ZHANG Peng
ZHANG Zhao-ying
AN Yan-hong
Abstract：Objective To investigate effects of monocyte chemotactic protein-1 (MCP -1), tumor necrosis factor-α (TNF-α),interleukin-6(IL-6) and hypersensitive c-reactive protein(hs-CRP) levels in peripheral blood on function of vascu-lar access in patients with maintenance hemodialysis uremia. Methods A total of 53 patients with uremic maintenance hemodi-alysis were divided into 3 groups according to different vascular accesses. Patients who underwent hemodialysis treatment after the first time of internal arteriovenous fistula operation were used as group A(n=17);patients who had normal vascular access during hemodialysis treatment were used as group B (n=20); patients who had abnormal vascular access during hemodialysis treatment were used as group C(n=16). Inflammation indexes among three groups and pathological indexes in group A and C were observed and compared,and correlations between hs-CPR level with age,hemodialysis time and pathological indexes were also analyzed. Results There were significant differences in TNF-α,IL-6 and hs-CRP among three groups(P<0.05). TNF-α,IL-6 and hs-CRP levels in group C were significantly higher than those in group A and B (P<0.05). In group C, intima thickness value of radial artery was larger,and CD68 and MCP-1 expressions on radial artery wall were significantly higher than those in group A(P<0.05). Correlation analysis showed that hs-CRP levels were positively correlated with age,hemodialysis time,intima thickness of radial artery and expressions of MCP-1 and CD68 on radial artery wall in patients with maintenance he-modialysis uremia. Conclusion Inflammatory reaction is one of the reasons leading to loss of vascular access function in pa-tients with maintenance hemodialysis uremia. MCP-1,TNF-α,IL-6 and hs-CRP levels in peripheral blood of patients with main-tenance hemodialysis uremia are very important in maintaining the stable function of vascular access.
Keywords：UremiaRenal dialysisChemokine CCL2Tumor necrosis factor-αInterleukin-6Hypersensitive C-reactive protein
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 91-94 )