Levels of HMGB-1 and RAGE in Cerebrospinal Fluid in Patients with Intracranial Infection after Severe Craniocerebral Trauma
MAO Xiu-hong
SUN Wei-he
JIN Xiang-bing
Abstract：Objective To investigate the expression level of HMGB-1 (HMGB-1) and advanced glycation end products recep-tor ( RAGE) in cerebrospinal fluid of patients with intracranial infection after severe craniocerebral trauma and its clinical significance. Methods 62 patients with severe craniocerebral trauma were selected as subjects admitted to our hospital from July 2014 to May 2016. According to the criteria of diagnosis and exclusion, the patients were divided into infection group (n=46) and non infection group (n=16 cases). The levels of HMGB-1 and RAGE in cerebrospinal fluid were measured by ELISA. Results The levels of HMGB-1 was (224. 67 ± 75. 48)ng/ml and RAGE was (160. 32 ± 42. 17)ng/ml in patients with intracranial infection were significant-ly higher than those in non-intracranial infection group (P<0. 01). There is no difference between the two groups in PCT, CRP, LA, LDH and other biochemical changes (P>0. 05), IL-6, and IL-8 in inflammatory markers IL-12, TNF- alpha, infection group were higher expression level and non-infection group, and two patients in group IFN-γ, IL-1, IL-4, beta gamma, IL-10 there is no differ-ence in IL-15 (P<0. 01). Conclusion The expression levels of HMGB-1 and RAGE in cerebrospinal fluid of patients with intracra-nial infection are higher than those of non-intracranial infection, detection of intracranial infection in patients after surgery has a certain diagnostic value.
Keywords：Brain injuriesInfectionPostoperative complicationsHigh mobility group protein-1Advanced advanced gly-cation end products receptor
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 70-73 )