Value of APACHE Ⅱ Score and Plasma Vwf in Evaluation of Prognosis of Patients with Acute Respiratory Distress Syndrome

XIA Lei

doi:10.3969/j.issn.1002-3429.2017.12.031

Abstract：Objective To investigate acute physiology and chronic health evaluation systemⅡ( APACHEⅡ) score and plasma von willebrand factor ( vWF) in diagnosis of degree of lung injury and value in evaluation of prognosis of patients with acute respiratory distress syndrome ( ARDS) . Methods A total of 90 ARDS patients admitted during March 2014 and February 2017 were divided into survival group (n=60) and death group (n=30) according to the prognosis. In two groups, APACHE Ⅱ scores, vWF levels, changes in lung injury score and oxygenation index on the 1st d and 3rd d after confirming the diagnosis of ARDS were analyzed, and relations between APACHEⅡscore and vWF with prognosis were analyzed. Results Compared with those in death group, in survival group, vWF levels, APACHE Ⅱ scores and lung injury scores on the 1st d and 3rd d after confirming the diagnosis of ARDS were significantly lower, while values of oxygenation indexes were significant-ly higher (P<0. 05). Compared with those on the 1st d and 3rd d after confirming the diagnosis of ARDS, vWF levels and APACHEⅡ scores were significantly higher, while lung injury score was significantly lower in survival group, and the scorewas significantly higher in death group (P<0. 05). On the 1st d and 3rd d after confirming the diagnosis of ARDS, APACHEⅡ scores and vWF levels were positively correlated with lung injury score. Areas under the receiver-operating characteristic (ROC) curve of vWF and APACHE Ⅱscore on the 1st d after confirming the diagnosis of ARDS were 0. 91 and 0. 87, while areas under the ROC curve on the 3rd d after confirming the diagnosis of ARDS were 0. 68 and 0. 61 respectively. Conclusion APACHE Ⅱ score and vWF level have application value in diagnosis of degree of lung injury and value in evaluation of prognosis of patients with ARDS.