Correlation of Serum Homocysteine and Cardiac Function in Chronic Heart Failure Elderly Patients with Coronary Atherosclerotic Heart Disease

ZHU Hong; MA Li-na; LIU Chuan; YANG Wei; LI Yun; QIAN Yu-ying

doi:10.3969/j.issn.1002-3429.2017.12.028

Abstract：Objective To observe correlation between serum homocysteine (Hcy) levels and cardiac function in chronic heart failure ( CHF) elderly patients with coronary atherosclerotic heart disease ( CAD) . Methods A total of 62 eld-erly patients with CAD were selected as CAD group, and the patients were divided into CHF subgroup (n=42) and cardiac function compensatory subgroup (n=20) according to cardiac function classification criteria from New York Heart Association ( NYHA) , and then CHF subgroup were divided into NYHA grade Ⅱ subgroup and NYHA grade Ⅲ-Ⅳ subgroup; other 20 healthy elderly patients taking medical examination at the same period were selected as control group. Changes of serum Hcy, n-terminal pro-b-type natriuretic peptide ( NT-proBNP) , left ventricular ejection fraction ( LVEF) and left ventricular end di-astolic dimension ( LVEDD) were compared, and correlations between serum Hcy levels with NT-proBNP, LVEF and LVEDD were analyzed in all groups and subgroups. Results Compared with those in control group, serum Hcy and NT-proBNP levels in compensatory and CHF subgroups and LVEDD level in CHF subgroup were significantly increased, while LVEF level in CHF subgroup was decreased (P <0. 05). Compared with those in compensatory subgroup, serum Hcy, NT-proBNP and LVEDD levels were significantly increased, while LVEF level was significantly decreased in CHF subgroup (P <0. 05). There were significant differences in serum Hcy and NT-proBNP levels between NYHA grade Ⅱ and NYHA gradeⅢ-Ⅳsub-groups (P<0. 05). Serum Hcy level in CHF elderly patients with CAD were positively correlated with NT-proBNP and LVEDD levels, and negatively correlated with LVEF level. Conclusion Serum Hcy level in CHF elderly patients with CAD significantly increases, and it is significantly correlated with NT-proBNP, LVEF and LVEDD levels, which can be used as an index in reflection of severity of heart failure.