Levels and Diagnostic Significances of Urinary NGAL, KIM-1 and IL-18 in Patients with Acute Traumatic Renal In-jury
WANG Lei
Abstract：Objective To investigate expression levels and diagnosed significances of urinary neutrophil gelatinase li-pocalin (NGAL), renal injury molecule-1 (KIM-1) and interleukin-18 (IL-18) in patients with acute traumatic renal injury. Methods A total of 50 patients with acute traumatic kidney injury, who had met inclusion and exclusion standard, were se-lected as trauma group, and other 50 healthy people taking medical examination were selected as control group. Levels of uri-nary NGAL, KIM-1, IL-18 and serum creatinine (SCr) at the time of admission in trauma group and taking medical examina-tion in control group, and urinary NGAL, KIM-1, IL-18 and SCr levels at different times in trauma group were observed and compared. The relations between urinary NGAL, KIM-1 and IL-18 with SCr in trauma group were analyzed, and receiver op-erating curve (ROC) was simultaneously drawn to evaluate significances of NGAL, KIM-1, IL-18 and SCr levels in diagnosis of acute traumatic kidney injury. Results In trauma group, urinary NGAL, KIM-1, IL-18 and SCr levels at the time of ad-mission were significantly higher than those at the time of taking medical examination in control group (P<0. 05). In patients with acute traumatic renal injury, urinary NGAL, KIM-1, IL-18 and SCr levels were gradually increased with prolonged hospi-tal stay, and the differences in same indicator at different times were statistically significant ( P <0. 05 ) . Urinary NGAL, KIM-1 and IL-18 levels were positively related to SCr level in patients with acute traumatic renal injury. Urinary NGAL level on the 8th h after admission and NGAL, KIM-1, IL-18 and SCr levels on the 24thh after admission had significances in diagno-sis of patients with acute traumatic renal injury. Conclusion Urinary NGAL, IL-18 and KIM-1 levels in patients with acute traumatic renal injury can be found significantly increased before SCr level will be increased, and urinary NGAL, IL-18 and KIM-1 levels have diagnosed significances, and therefore urinary NGAL, IL-18 and KIM-1 can be used as biomarkers in early diagnosis of patients with acute traumatic renal injury.
Keywords：Acute kidney injuryWounds and injuriesNeutrophil gelatinase lipocalinRenal injury molecule-1Interleukin-18
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 82-85 )